Project 3: Argument Map: Creatine supplementation effect on recovery following exercise-induced muscle damage by Joshua Lim

Argument: Creatine reduces muscle damage and increases muscle function after Exercise-induced muscle damage

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Exercise-induced muscle damage (EIMD)

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Creatine Supplementation

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Creatine: a substance that helps you produce energy for your muscles.

Muscle growth

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Muscle growth involves many factors, including muscle damage. When you exercise, you put stress on your muscles, which can cause tiny tears in the muscle fibers. This is called muscle damage. Your body responds to this damage by repairing and rebuilding the muscle fibers, which can make them bigger and stronger over time

Accelerated muscle Recovery due to supplementation

jil68_ — 2023-11-22 00:16:55 UTC

"Creatine supplementation would be effective in reducing the immediate muscle damage that happens <24, 24, 48, 72, and 96 hr post-exercise. In the current meta-analysis, the positive effects of creatine could cause a decrease in CK concentration overall"(Jiaming, Rahimi, 1)

creatine kinase (CK)

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enzyme: mainly exists in heart and skeletal muscle. When these tissues are damaged creatine kinase leaks into your bloodstream.

lactate dehydrogenase (LDH)

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LDH is present in most body tissues. When tissues in your body experience damage or injury, they release excess LDH into your bloodstream

Reduce Concentration of CK and LDH in immediate after EIMD

jil68_ — 2023-11-22 00:46:03 UTC

"Pooled data showed that creatine significantly reduced creatine kinase (CK) concentration overall (WMD = −30.94; 95% CI: −53.19, −8.69; p = .006) and at three follow-up times (48, 72, and 96 hr) in comparison with placebo. In contrast, effects were not significant in lactate dehydrogenase (LDH) concentration overall (WMD = −5.99; 95% CI: −14.49, 2.50; p = .167), but creatine supplementation leaded to a significant reduction in LDH concentrations in trials with 48 hr measurement of LDH."(Jiaming, Rahimi, 1).

jil68_ — 2023-11-22 00:59:08 UTC

"Proteins like CK and LDH have been extensively applied as markers of muscle micro-damages (Ghaderi et al., 2012) and usually has been evaluated to be indirect biomarkers of post-exercise muscle damage due to their easiness of identification and the relatively low cost of tests to quantify it (Rahimi et al., 2017; Rodrigues et al., 2016)." (Jiaming, Rahimi, 25).

Side effects

jil68_ — 2023-11-22 01:02:52 UTC

"Weight gain is the only side effect that has been suggested which may be a desirable effect for many patients and athletes (Earnest et al., 1995; Juhn, 1999; Kutz & Gunter, 2003). "(Jiaming, Rahimi, 30)