3) released at ganglia from presynaptic nerve endings

- Norepinephrine (NE)-adrenergic
3) released at postganglionic nerve endings, by adrenal medulla and neurons

- Epinephrine (EPI)-adrenergic
3) produced by adrenal medulla

-Dopamine (DA)
3) NT released at ganglia from presynaptic nerve endings (both systems)

4) Receptors for this division...

-alpha 1; located on glands, smooth muscles, eyes, most arteries and veins
5) smooth muscle contraction and vasoconstriction leads to an increase in blood pressure, pupils are dilated

-beta 1; located on the heart
5) heart's force of contraction, rate of contraction, and conduction are all increased

-beta 2; located on smooth muscle, lungs, uterus, skeletal muscle arteries, coronary arteries
5) smooth muscle relaxation, bronchodilation, uterine relaxation, vasodilation of coronary and skeletal muscle vessels

6)  Drug classifications for this division...

- Sympathomimetics: drugs that mimic the sympathetic system (adrenergics, agonists)

- Alpha-1 Adrenergic Agonists; alpha-1 receptor is stimulated

7) phenylephrine (Neo-Synephrine®) 

- Adrenergic Agonists; stimulates all alpha and beta receptors

7) epinephrine (Adrenalin®) 

-Beta Adrenergic Agonists; depends on the dose, at a low dose they stimulate dopaminergic (d-1) receptors, at a moderate dose they stimulate beta 1 receptors, at a high dose they stimulate alpha-1 receptors

7) dobutamine (Dobutrex®)

-Beta Adrenergic Agonists; stimulates beta 2 receptors

7) albuterol (Proventil®, Ventolin®), terbutaline (Brethine®), formoterol (Foradil®), salmeterol (Serevent®)

 

 

- Sympatholytics: drugs that work against the sympathetic system (adrenergic blocking, blockers, inhibitors, antagonists) 

- Alpha-1 Adrenergic Blocking Drugs; binds to alpha-1 receptors and blocks them 

7) prazosin (Minipress®), terazosin (Hytrin®), doxazosin (Cardura®)

- Beta-Adrenergic Blocking Drugs; beta-1 receptor is blocked (antagonizes beta-1 effects of NE and EPI)

7)  atenolol (Tenormin®), metoprolol (Lopressor®) 

-Beta-Adrenergic Blocking Drugs; block beta-1 and beta-2 receptors 

7) nadolol (Corgard®), propanolol (Inderal®), timolol (Blocadren®) 

 

 

 

3) released at ganglia from presynaptic nerve endings

- Norepinephrine (NE)-adrenergic
3) released at postganglionic nerve endings, by adrenal medulla and neurons

- Epinephrine (EPI)-adrenergic
3) produced by adrenal medulla

-Dopamine (DA)
3) NT released at ganglia from presynaptic nerve endings (both systems)

4) Receptors for this division...

-muscarinic; located on cardiac, smooth muscle, and glands at parasympathetic postganglionic nerve endings
5) decrease heart rate, bronchoconstriction, digestion, GI secretions, and 

urination, pupillary constriction
 

-nicotinic 1 (Nn): located at ganglia of parasympathetic nerves and sympathetic nerves 
 5) muscle contraction

-nicotinic 2 (Nm): located at neuromuscular junction of skeletal muscle 

5) muscle contraction

6)  Drug classifications for this division...

- Parasympathomimetics: drugs that mimic the parasympathetic system (agonists, cholinergics)

- Direct–Acting Cholinergic Agonists; bind to the muscarinic receptors in the parasympathetic division 

7) pilocarpine (Pilocar® ), bethanechol (Urecholine®)

- Indirect –Acting Cholinergic Agonists; inhibit acetylcholinesterase, the enzyme that destroys ACH in the synapse 

7) neostigmine (Prostigmin®), rocuronium bromide (Zemuron®) 

- Parasympatholytics: drugs that work against parasympathetic system (antagonists, anticholingerics) 

- Anticholinergics/Parasympatholytics; bind to a cholinergic receptor 

7) dicyclomine (Bentyl®), ipratropium bromide (Atrovent®)