Moderate dose-stimulates  beta 1 receptors-heart, increases force of contraction and cardiac output 

High dose- stimulates alpha-1 receptors causing vasoconstriction  increase in blood pressure
DRUGS:

dobutamine

Beta-2:
stimulates beta 2 receptors 

relaxation of the smooth muscle of the lungs- bronchodilation 

relaxation of the smooth muscle of the uterus
DRUGS: 
albuterol (Proventil®, Ventolin®)-bronchodilator

terbutaline (Brethine®)-bronchodilator, uterine relaxant

formoterol (Foradil®)-bronchodilator

salmeterol (Serevent®)-bronchodilator

Beta- Adrenergic Blocking Drugs-
Selective Beta-1 Blockers:
beta-1 receptor is blocked (antagonizes beta-1 effects of NE and EPI)    

decreases force of contraction  (negative inotropic), decreases cardiac output

decreases HR  (negative chronotropic) 

decreases conduction (negative dromotropic)

decrease in cardiac output also decreases BP

DRUGS:
atenolol (Tenormin®)

metoprolol (Lopressor®)

Non-selective Beta Blockers:
block beta-1 and beta-2 receptors 

decreases force of contraction  (negative inotropic), decreases cardiac output

decreases HR  (negative chronotropic) 

decreases conduction (negative dromotropic)

decrease in cardiac output also decreases BP

can cause bronchoconstriction

DRUGS:
nadolol (Corgard®)

propanolol (Inderal®)
timolol (Blocadren®)

mimics ACH

DRUGS:
acetylcholine-used for miosis, cataract and other eye surgeries

MOA: pupil constriction

pilocarpine (Pilocar® )-used for glaucoma

MOA: pupil constriction; decreases amount of fluid in eye; decreases  intraocular pressure

bethanechol (Urecholine®)-used for urinary retention and ileus/intestinal stasis
MOA: stimulates muscarinic receptors of bladder and GI tract to prevent constipation and urinary retention post-op                                              and in the elderly

Indirect –Acting Cholinergic Agonists-
inhibit acetylcholinesterase, the enzyme that destroys ACH in the synapse

increases ACH
DRUGS:
neostigmine (Prostigmin®)

Cholinergics/Parasympathomimetics:
Direct –Acting Cholinergic Agonists-
directly stimulate/bind to the muscarinic receptors in the parasympathetic division 

mimics ACH
DRUGS:

acetylcholine-used for miosis, cataract and other eye surgeries

MOA: pupil constriction

pilocarpine (Pilocar® )-used for glaucoma

MOA: pupil constriction; decreases amount of fluid in eye; decreases  intraocular pressure

bethanechol (Urecholine®)-used for urinary retention and ileus/intestinal stasis

MOA: stimulates muscarinic receptors of bladder and GI tract to prevent constipation and urinary retention post-op                                              and in the elderly

Indirect –Acting Cholinergic Agonists
inhibit acetylcholinesterase, the enzyme that destroys ACH in the synapse

increases ACH
DRUGS:
neostigmine (Prostigmin®)