XMEN Disease by EASTON HOFFMAN https://padlet.com/89410/z5a72tojh1bx By Easton Hoffman and Page Schoer en-us 2016-02-16 15:23:23 UTC 2023-02-19 04:51:36 UTC hello@padlet.com http://blogs.scientificamerican.com/blogs/cache/file/7CF78ACB-DF34-4800-868C6F11372042A1.jpg Genetic Counselor (Page) 89360 https://padlet.com/89410/z5a72tojh1bx/wish/95303947 A. Classification
  • Single gene defect classification (XMEN)
  • Inherited in an X-linked recessive pattern (XMEN)
B. Disorder arousal
  • Recessive
  • Refer to Pedigree Chart
C. Frequency
  •  Very rare, more common in men than in women (Johnson)
D. Advisement
  • Individualized supplement intake (General Care)


]]> 2016-02-16 15:26:18 UTC https://padlet.com/89410/z5a72tojh1bx/wish/95303947 Disorder Specialist (Easton) 89410 https://padlet.com/89410/z5a72tojh1bx/wish/95304071 Name
  • XMEN Disease aka immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection, and neoplasia
Gene Location/Karyotype
  • Located on the X chromosome
  • Mutation is located on the longer arm of the X chromosome in the 21.1. on the MAGT1 gene (MAGT1)
]]> 2016-02-16 15:26:36 UTC https://padlet.com/89410/z5a72tojh1bx/wish/95304071 Works Cited - Page 89360 https://padlet.com/89410/z5a72tojh1bx/wish/95452357
"XMEN." Genetics Home Reference. US National Library of Medicine, June 2014. Web. 16 Feb. 2016.

Johnson, Cort. "The Epstein-Barr Virus, Magnesium and ME/CFS Connection." SimmaronResearch.com. Simmaron Research, 22 Aug. 2015. Web. 16 Feb. 2016.

"General Care." PrimaryImmune.org. Immune Deficiency Foundation, n.d. Web. 16 Feb. 2016]]> 2016-02-17 01:43:31 UTC https://padlet.com/89410/z5a72tojh1bx/wish/95452357 Disorder Specialist (Easton) 89410 https://padlet.com/89410/z5a72tojh1bx/wish/95453386 Signs and Symptoms
  • Symptoms include constant infections such as recurrent otitis media, sinusitis, viral pneumonia, diarrhea, upper respiratory infections, epiglottitis, and pertussis. (Signaling)
  • Basically lots of infections.
  • Caused by the lack of function of T-cells (cells that fight against infections and disease) due to lack of magnesium transporter
  • Magnesium transporter production is slowed by XMEN disease
Possible Treatments 
  •  Treatments include Hematopoietic stem cell transplant, replacing mutated gene with a new, normal gene. Effectiveness of transplant has been proven.
  • Continuous oral magnesium threonate supplementation has shown promising results (Genetic)
Life Expectancy 
  •  The life expectancy of a victim of EBV lymphoma can be as small as about 30 d (most commonly a result of XMEN)
Prenatal Testing 
  •  Prenatal tests consist of collected samples of magnesium transporter from the baby and testing the effectiveness and the amount of magnesium transporter present in the body.
]]> 2016-02-17 01:55:27 UTC https://padlet.com/89410/z5a72tojh1bx/wish/95453386 Works Cited - Easton 89410 https://padlet.com/89410/z5a72tojh1bx/wish/95458369
"Genetic Analysis of Immune Disorders - Full Text View - ClinicalTrials.gov." Home - ClinicalTrials.gov. N.p., n.d. Web. 16 Feb. 2016.

"MAGT1 - Magnesium Transporter 1." Genetics Home Reference. N.p., n.d. Web. 16 Feb. 2016.

"Signaling Role for Mg2+ Revealed by Immunodeficiency Due to Loss of MagT1." PubMed Central (PMC). N.p., n.d. Web. 16 Feb. 2016.
]]> 2016-02-17 03:00:44 UTC https://padlet.com/89410/z5a72tojh1bx/wish/95458369