Angelman Syndrome by Kathryn Homer 19 https://padlet.com/kahomer19/ypsy998zd7f2 Genetic Disease en-us 2018-03-22 17:03:54 UTC 2018-03-29 00:27:26 UTC hello@padlet.com Disease Discription kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/245127469 Angelman Syndrome is a genetic disorder that primarily affects the nervous system.  Many of the characteristics of Angelman Syndrome are derived from the loss of function of the gene called "UBE3A".]]> 2018-03-22 17:14:20 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/245127469 Initial Symptoms kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/245133341 Children affected usually experience delayed development, intellectual disability, severe speech impairment, and problems with movement and balance.  Other common features include unusually fair skin and light colored hair.  Frequent laughter, smiling, and hand-flapping movements are also common.  ]]> 2018-03-22 17:23:47 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/245133341 Common Treatments kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/245140408 Although there is no cure for Angelman Syndrome right now,  researchers are focusing on targeting specific genes for treatment. Current treatment focuses on managing the medical and developmental issues.These treatments include anti-seizure medication, physical therapy, communication therapy, and behavior therapy. All of these treatments are used mainly to control that side effects that come with the disease.

]]> 2018-03-22 17:34:22 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/245140408 Works Cited kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/246140147 “Angelman Syndrome - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, 20 Mar. 2018, ghr.nlm.nih.gov/condition/angelman-syndrome.


“Angelman Syndrome.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 2 Mar. 2018, www.mayoclinic.org/diseases-conditions/angelman-syndrome/diagnosis-treatment/drc-20355627.


“Angelman Syndrome.” NORD (National Organization for Rare Disorders), 2018, rarediseases.org/rare-diseases/angelman-syndrome/.


“What Is AS?” Angelman Syndrome Foundation, www.angelman.org/what-is-as/.


“Angelman Syndrome | FAST.” FAST (Foundation for Angelman Syndrome Therapeutics), cureangelman.org/understanding-angelman.

]]> 2018-03-26 15:30:46 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/246140147 Side Effects kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/246151887 -Seizures are common, usually beginning at age two. 
-Stiff or jerky movements, along with small head size, and flatness in the back of the head.
-Tongue thrusting is usually seen in children with Angelman Syndrome.
-Unusual behaviors, such as hand flapping and arms uplifted while walking, and excessive laughter is common.

]]> 2018-03-26 15:50:00 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/246151887 Prevention/Control kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/246719523 There are no known prevention methods or ways to control this disease. ]]> 2018-03-27 23:50:02 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/246719523 kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247000976 2018-03-28 17:16:10 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247000976 Chromosome 15 kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247003547 Angelman Syndrome can sometimes be cause by a chromosomal rearrangement, called translocation, or by a defect in the region of DNA that controls the activation of the UBE3A gene. The UBE3A gene is associated with chromosome 15. Genetic changes like these can turn off UBE3A or other genes on the maternal copy of chromosome 15. ]]> 2018-03-28 17:21:22 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247003547 kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106857 2018-03-29 00:12:13 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106857 kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106858 2018-03-29 00:12:13 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106858 Inheritance of Angelman Syndrome kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106997 Most cases of Angleman Syndrome are not inherited. Angelman Syndrome is caused by a deletion in the maternal chromosome 15, whihc is why there is no known genetic inheritance. These genetic changes occur randomly during the formation of the sperm and egg cells. ]]> 2018-03-29 00:13:18 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247106997 Population kahomer19 https://padlet.com/kahomer19/ypsy998zd7f2/wish/247107961 Angelman Syndrome affects males and females at a very similar rate. The deletion in chromosome 15 occurs in about 1 in 12,000-20,000 births. ]]> 2018-03-29 00:20:12 UTC https://padlet.com/kahomer19/ypsy998zd7f2/wish/247107961