https://padlet.com/yx2017be/yj7pmv735gr Basics about the Signaling Pathway knowledge. https://www.bocsci.com en-us 2018-09-15 05:43:02 UTC 2018-09-15 06:03:35 UTC hello@padlet.com yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281584840 The Notch signaling pathway is a highly conserved set of intercellular communication mechanisms. The Wnt and Notch signaling pathways interact and coordinate development in embryonic development, tissue regeneration, and tumor formation. The notch can bind to β-catenin to inhibit the Wnt signaling pathway, induce cycle arrest and apoptosis in human tongue cancer cells; Wnt activates Dvl against Notch signaling pathway.]]> 2018-09-15 05:44:59 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281584840 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281584972 VEGF-A mainly binds to VEGFR-2 to promote tumor angiogenesis, while other VEGF members such as VEGF-C and VEGF-D can bind to corresponding receptors and participate in tumor lymphatic metastasis. VEGF-C produced by gastric cancer cells not only binds to VEGFR-3 on the vascular endothelium in a paracrine manner, induces angiogenesis, but also promotes the growth and migration of gastric cancer cells by autocrine binding to VEGFR-3.]]> 2018-09-15 05:46:36 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281584972 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281585149 The Notch signaling pathway regulates cellular identity, proliferation, differentiation and apoptosis by means of cell–cell interactions. It also plays a crucial role in a wide array of developmental processes, including the regulation of neurogenesis, myogenesis, angiogenesis, hematopoiesis and epithelial to mesenchymal transition, and tissue homeostasis. Notch signaling has recently been shown to interact with several of the other key signaling mechanisms.]]> 2018-09-15 05:49:05 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281585149 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281585340  The normal operation of the insulin signal pathways plays an important role in insulin physiological function. The disorder of insulin signal transduction will weak the physiological action of insulin, leading to insulin resistance and type 2 diabetes mellitus. Insulin resistance refers to the decrease in insulin utilization rate and insulin sensitivity caused by various reasons, which is the main pathological basis of type 2 diabetes. ]]> 2018-09-15 05:51:41 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281585340 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281585458 Studies have suggested that IL-1RI undergoes a conformational change when binding IL-1β and allows the IL-1RAcP to form the heterodimer. The cytoplasmic domain of IL-1RI is unique in that it contains homology to the Drosophila Toll protein, termed the TIR domain. The TIR domain is also found in the cytoplasmic domains of each TLR. The TIR domains of IL-1RI and also of the coreceptor IL-1RAcP are necessary for signal transduction. Although most cells express IL-1RI constitutively, expression of IL-1RAcP is not constitutive in some cells. ]]> 2018-09-15 05:53:24 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281585458 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281585626 AMPK signaling pathway, as a master regulator of cellular energy homeostasis, we need have a good understanding of the mechanistic of AMPK function, focusing on a number of new identified upstream/downstream effectors of AMPK. So we can know which targets are essential and relevant for the beneficial effects of AMPK activation seen in pathological states ranging from diabetes to cancer to neurological disorders.]]> 2018-09-15 05:55:47 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281585626 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281585767 The core process for autophagy is the formation of a 300- to 900-nm diameter doublemembrane organelle, the autophagosome. Autophagosome biogenesis can be divided into the following stages: (1) trigger/initiation; (2) nucleation-assembly of an isolation membrane (phagophore); (3) elongation/extension of the phagophore; and (4) maturation of the phagophore by membrane closure (phagosome) followed by fusion with the lysosome.]]> 2018-09-15 05:58:04 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281585767 yx2017be https://padlet.com/yx2017be/yj7pmv735gr/wish/281586091 The activated GTP-bound RAS has several downstream effector enzymes, and it is through these kinase systems and the associated pathways that RAS controls cell proliferation, survival and other aspects of cell behaviour. Therapeutic interventions that target these enzymes might therefore be effective in treating tumours in which RAS is mutationally activated.]]> 2018-09-15 06:03:04 UTC https://padlet.com/yx2017be/yj7pmv735gr/wish/281586091