Measuring biofluid dynamics by Hanrahan, Sara https://padlet.com/shanrahan3/BME341 in silico, in vitro, and in vivo en-us 2019-12-02 15:20:31 UTC 2019-12-02 18:55:51 UTC hello@padlet.com in silico, in vitro, or in vivo biofluid mechanics study https://padlet.com/shanrahan3/BME341/wish/418510857 What is the measurement method?
How does method work?
Area of the body?
Purpose of study?
Advantages of method? Disadvantages of method?
Where did you find this information?
Weirdest study wins candy]]> 2019-12-02 15:23:16 UTC https://padlet.com/shanrahan3/BME341/wish/418510857 https://padlet.com/shanrahan3/BME341/wish/418605361 2019-12-02 17:30:09 UTC https://padlet.com/shanrahan3/BME341/wish/418605361 https://padlet.com/shanrahan3/BME341/wish/418605771 -In silico
-Method: CFD modeling
-How it works: CFD simulation enables detailed characterisation of complex physiological pressure and flow fields and the computation of metrics which cannot be directly measured
-Area: cardiovascular system
-Purpose: To have a computational model of the cardiovascular system that physicians can use in clinical applications
-Advantage: provides data and understanding that cannot be found using any other method
-Disadvantages: There are very few government regulations concerning the validity, reliability, or accuracy of this information. Also the necessary information found from hospitals can be restrictive and hard to use.]]> 2019-12-02 17:30:44 UTC https://padlet.com/shanrahan3/BME341/wish/418605771 Role of Fluid Mechanics in Localization and Detection of Atherosclerosis https://padlet.com/shanrahan3/BME341/wish/418606870
-In Vitro
-Using Doppler velocimeter, measure velocity disturbance to find points of atherosclerosis.
- Carotid artery
-Non invasive]]> 2019-12-02 17:32:05 UTC https://padlet.com/shanrahan3/BME341/wish/418606870 https://padlet.com/shanrahan3/BME341/wish/418607041 2019-12-02 17:32:19 UTC https://padlet.com/shanrahan3/BME341/wish/418607041 https://padlet.com/shanrahan3/BME341/wish/418607883 2019-12-02 17:33:19 UTC https://padlet.com/shanrahan3/BME341/wish/418607883 Biofluid Biomarkers of Traumatic Brain Injury https://padlet.com/shanrahan3/BME341/wish/418608318 Method:CNS-derived exosomes analyzed by ultra-high sensitivity detection
Area: Brain
Purpose: identifying, diagnosing, and treating the underlying individual pathobiological changes of traumatic brain injury
Advantage: noninvasive
Disadvantage: Blood biomarker still not available
Information: https://www.tandfonline.com/doi/full/10.1080/02699052.2017.1357836

]]> 2019-12-02 17:33:51 UTC https://padlet.com/shanrahan3/BME341/wish/418608318 The fluid mechanics of root canal irrigation https://padlet.com/shanrahan3/BME341/wish/418608562 https://iopscience.iop.org/article/10.1088/0967-3334/31/12/R01/meta

-In Vitro
Method- Observing differing stagnation points with different insertion needles and methods
-Teeth, specifically the roots and canals inside the tooth
-Advantage- By maintaining a constant volume flow rate and with side-discharging needles, the effectiveness of canal cleaning is increased.
-Disadvantage- There remains a lack of clarity about the mechanisms of irrigant delivery, replenishment, mixing, flushing and wall erosion of the tooth]]> 2019-12-02 17:34:10 UTC https://padlet.com/shanrahan3/BME341/wish/418608562 https://padlet.com/shanrahan3/BME341/wish/418609628 https://www.sciencedirect.com/science/article/pii/S0041008X13001063?via%3Dihub]]> 2019-12-02 17:35:25 UTC https://padlet.com/shanrahan3/BME341/wish/418609628 in vitro sdobbs11 https://padlet.com/shanrahan3/BME341/wish/418609770 -heart pulsed flow simulator
-ventricle made of transparent silicone rubber connected to test valves and a standard 23 mm aortic value in mitral and aortic positions respectively in a way that they could open and close freely with flow 
-heart
-to see how the profile height of the mitral bioprosthetic valve changes the blood flow behavior
-this method allows for a close model to actual blood flow in vivo and allows for various sized bioprosthetic valves to be tested
-this model is not involving the factors of platelet activation and aggregation which may result in high shear rates and deformation, so additional tests need to be done to establish the true character of the bioprosthetics


https://journals.lww.com/asaiojournal/Fulltext/2006/01000/An_In_Vitro_Study_of_Changing_Profile_Heights_in.7.aspx]]> 2019-12-02 17:35:35 UTC https://padlet.com/shanrahan3/BME341/wish/418609770 Numerical simulation of the dynamics of a bileaflet prosthetic heart valve using a fluid–structure interaction approach https://padlet.com/shanrahan3/BME341/wish/418610281 In Silico 
Method - Fluid Structure Interaction (FSI) Method 
How - model created using GAMBIT software, using finite volume coding 
Area of Body - heart valve
Purpose - showing how to reproduce the effects of a 27 mm mechanical heart valve 
Advantage - "modeling a more realistic geometry"
Disadvantage - there was a much smaller magnitude gap between the fluid and the valve that was manufactured]]> 2019-12-02 17:36:12 UTC https://padlet.com/shanrahan3/BME341/wish/418610281 Reproducibility of Image-Based Analysis of Cerebral Aneurysm Geometry and Hemodynamics: An In-Vitro Study of Magnetic Resonance Imaging, Computed Tomography, and Three-Dimensional Rotational Angiography https://padlet.com/shanrahan3/BME341/wish/418610395 -computational fluid dynamics (CFD) modelling using Navier-Stokes equation
-steady laminar flow was simulated in reconstructions; blood was modeled as a non-Newtonian fluid; 
-model of aneurysms in the brain
-purpose is to model cerebral aneurysms and compare different imaging methods of phantom models
-advantages: easily compare models to see if which imaging device is the best or if any alter the geometry of the aneurysm in any way
-disadvantages: doesn't propose a solution or have a way to treat the differences

]]> 2019-12-02 17:36:20 UTC https://padlet.com/shanrahan3/BME341/wish/418610395 In silico modeling to predict drug-induced phospholipidosis https://padlet.com/shanrahan3/BME341/wish/418610396 -in silico quantitative structure–activity relationship (QSAR) modeling
-Quantitative structure–activity relationships (QSAR) are mathematical relationships linking chemical structure and pharmacological activity in a quantitative manner for a series of compounds. Methods which can be used in QSAR include various regression and 
pattern recognition
 techniques.
-predict drug-induced phospholipids
-Advantages: Provides invaluable data only easily obtainable with in silico testing
-https://www.sciencedirect.com/science/article/pii/S0041008X13001063?via%3Dihub
]]> 2019-12-02 17:36:20 UTC https://padlet.com/shanrahan3/BME341/wish/418610396 In Silico https://padlet.com/shanrahan3/BME341/wish/418611014 -3D Computer Modeling
-Data collected from patients undergoing Radioembolism set parameters for the simulation of blood vessels.
-The Hepatic Arterial System
-Understand blood flow when a tumor is present in the arterial system.
-Advantage: no need for a real person.
-Disadvantage: model may not apply to all cases.
https://www.sciencedirect.com/science/article/pii/S0360301609027205]]> 2019-12-02 17:37:07 UTC https://padlet.com/shanrahan3/BME341/wish/418611014 https://padlet.com/shanrahan3/BME341/wish/418611035 Method: 2d model with immersed boundary, used Navier-Stokes Theorem, Lagrangian mesh
Area: sperm/bodily fluids
Purpose: to better understand mammalian reproduction and the roles of flagellar and ciliary beating  
Advantage:
Disadvantage:
Information:]]> 2019-12-02 17:37:08 UTC https://padlet.com/shanrahan3/BME341/wish/418611035 In Vitro Study https://padlet.com/shanrahan3/BME341/wish/418611128 -Migrations of the stagnation points on the bottom of the anastomoses at mean Reynolds numbers
-transparent 1:1 casted replicas of distal vascular graft anastomoses created by conventional technique, Miller-cuff, Taylor- and Linton-patch were fabricated
-Vascular surgery
-To investigate flow patterns in four anastomotic types of femoral end-to-side distal bypass graft anastomoses
-Advantages: Miller-cuff has a wider cavity which shows the lower shift of the bottom stagnation point


https://www.sciencedirect.com/science/article/pii/S1078588498908024]]> 2019-12-02 17:37:16 UTC https://padlet.com/shanrahan3/BME341/wish/418611128 in silico https://padlet.com/shanrahan3/BME341/wish/418611138 compare accepted CT angiography data to CT, MRI, 3DRA. 
Test accuracy of these different methods]]> 2019-12-02 17:37:16 UTC https://padlet.com/shanrahan3/BME341/wish/418611138 -In vivo mkenne32 https://padlet.com/shanrahan3/BME341/wish/418611521 - Fix erectile dysfunction
-THE penis
-To target the blood flow and study how pressure difference influences penis circumference
- More successful management of patients
- Limited number of patients available to study because of requirements required for the study

]]> 2019-12-02 17:37:47 UTC https://padlet.com/shanrahan3/BME341/wish/418611521 Statistical wall shear stress maps of ruptured and unruptured middle cerebral artery aneurysms https://padlet.com/shanrahan3/BME341/wish/418613618 -insilico
-MCA Aneurysms
 -ZIBAmira software
-Animal and Human modeling

]]> 2019-12-02 17:40:31 UTC https://padlet.com/shanrahan3/BME341/wish/418613618 In vitro https://padlet.com/shanrahan3/BME341/wish/418614229 - laser Doppler anemometry (LDA) measurements
- Left ventricle of jellyfish heart
Study done to enhance understanding of thrombus formation hemolysis in dynamic flow heart prosthesis]]> 2019-12-02 17:41:20 UTC https://padlet.com/shanrahan3/BME341/wish/418614229 Microbubble-vessel Interactions https://padlet.com/shanrahan3/BME341/wish/418614455 -Microbubbles are utilized as a ultrasound contrast agent 
-In vivo / Ex vivo in rats. 
This was done in the mesentery
-The bubble will help with the ultrasound in the area and are also used in drug-delivery
-The bubbles may cause damage to the vessels 
-https://asa.scitation.org/doi/full/10.1121/1.4817843]]> 2019-12-02 17:41:39 UTC https://padlet.com/shanrahan3/BME341/wish/418614455 Wall-PIV measuring technique https://padlet.com/shanrahan3/BME341/wish/418618117 -In silico
-Time resolved 3D-PIV technique used for measuring near wall flow field measurements
-Uses diffuse, monochromatic full-field illumination and optical flow algorithm to estimate near wall flow
-Circulatory system
-Advantage: more limited to near wall region through the use of a molecular dye
-Disadvantage: new technique]]> 2019-12-02 17:45:59 UTC https://padlet.com/shanrahan3/BME341/wish/418618117 https://padlet.com/shanrahan3/BME341/wish/418619188 2019-12-02 17:47:14 UTC https://padlet.com/shanrahan3/BME341/wish/418619188