Group 4 by Mary Phelps https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy en-us 2021-05-26 16:09:16 UTC 2025-12-26 06:02:01 UTC hello@padlet.com Use and Action https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562019035 - Treats fever and pain
- causes dilation of peripheral blood vessels, enabling sweating and dissipation of heat
NOT an anti-inflammatory]]> 2021-05-26 16:12:29 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562019035 Brand: Tofranil https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562019433 T-class: antidepressant,
Pharmacological class: Tricyclic antidepressant


]]> 2021-05-26 16:12:34 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562019433 Luminal https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562020120 Therapeutic: sedative/ antiseizure
Phrmacologic: Barbituate, GABAA receptor agonist
Admin Alerts: schedule IV
OD severe resp. depression, CNS depression, coma and death
Drug-Drug:
Do not take with alcohol or other CNS depressants.]]> 2021-05-26 16:12:45 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562020120 Use and Action: maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562028264 - Blocks reuptake of serotonin & norepinephrine into nerve terminals
- Used mainly for major depression, can be used to treat nocturnal enuresis in children.
- Off-label: intractable pain, anxiety disorders, & withdrawal from alcohol and cocaine]]> 2021-05-26 16:14:40 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562028264 Administration https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562033613 Do not exceed 3,000mg in 24 hours
- Never administer to patients who consume alcohol regularly due to the potential for drug induced hepatotoxicity
- Overdose or long term use can cause severe and fatal liver injury, it is the number one cause of acute liver failure in the United States
Treatment for overdose: N-acetylcysteine (Acetadote) 
- Inhibits warfarin metabolism, causing it to accumulate to toxic levels
]]> 2021-05-26 16:15:54 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562033613 Admin Alerts maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562041593 - Paradoxical diaphoresis can be side effect of TCAs
- Anticholinergic effects: dry mouth, blurred vision, drowsiness, dizziness, constipation, n/v, & weight gain/loss; increased sweating may occur
- Do not discontinue abruptly because rebound dysphoria, irritability, or sleeplessness may occur.
- Pregnancy category C

]]> 2021-05-26 16:17:48 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562041593 Interaction: https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562043654 Drug to drug:
-  Cimetidine and methylphenidate may inhibit the metabolism of imipramine
- May reverse the antihypertensive effects of Clonidine and potentiate CNS depression

Lab tests:
- altered blood glucose test, serum bilirubin and alkaline phosphate

Food/ Herbal
evening primrose oil or ginkgo may lower seizure threshold, St John's wort 

]]> 2021-05-26 16:18:18 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562043654 Adverse Effects maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562052560 - sedation
- drowsiness 
- blurred vision
- dry mouth
- cardiovascular symptoms: dysrhythmias, heart block, & extreme hypertension
- some may experience photosensitivity & hypersensitivity to tricyclic drugs

]]> 2021-05-26 16:20:21 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562052560 Black Box Warning: maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562067427 Antidepressants increase the risk of suicidal thinking and behavior, especially in children, adolescents, & young adults with major depressive disorder & other psychiatric disorders.
This drug is not approved for use in pediatric patients.


]]> 2021-05-26 16:23:51 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562067427 Important Info https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562070803 does not cause GI bleeding or ulcers, as do the NSAIDs
- Advise patients that acetaminophen is found in many OTC products and that extreme 
care must be taken to not duplicate doses by taking several of these products concurrently.
]]> 2021-05-26 16:24:37 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562070803 Use and Action: https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562076931 - Long-acting barbiturate used to manage seizures
- acts biochemically by enhancing the action of the GABA  neurotransmitter, which is responsible for suppressing abnormal neuronal discharges that can cause epilepsy.
- used to promote sleep]]> 2021-05-26 16:26:03 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562076931 Contraindications maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562089740 - acute recovery after MI
- defects in bundle-branch conduction
- narrow-angle glaucoma
- severe renal or hepatic impairment
- Do not use this drug within 14 days of discontinuing MAOIs]]> 2021-05-26 16:29:07 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562089740 Admin Alerts maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562097324 - IM injection may produce a local inflammatory reaction
- IV admin rarely used b/c extravasation may produce tissue necrosis
- controlled substance: schedule IV
- Pregnancy category D]]> 2021-05-26 16:30:56 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562097324 Interactions maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562101931 Drug-Drug:
Do not take with alcohol or other CNS depressants.

Lab Tests:
Bromsulphalein tests & increase serum phosphate

Herbal/Food:
Kava & valerian may potentiate sedation]]> 2021-05-26 16:32:05 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562101931 Treatment of Overdose maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562111637 - no specific treatment
- general supportive measures are 
recommended
- monitor cardiac rhythm & VS
- gastric lavage may be indicated, activated charcoal should be administered]]> 2021-05-26 16:34:19 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562111637 Adverse Effects maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562145062 Common: drowsiness, vitamin D, folate (B9) & B12 deficiencies & laryngospasms

Overdose: severe respiratory depression, CNS depression, coma, & death]]> 2021-05-26 16:42:21 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562145062 Contraindications maryphelps1987 https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562152370 - hypersensitivity to barbiturates
- severe uncontrolled pain
- preexisting CNS depression
- porphyria
- severe respiratory disease w/dyspnea or obstruction
- glaucoma 
- prostatic hypertrophy]]> 2021-05-26 16:44:10 UTC https://padlet.com/maryphelps1987/yg1cetfsw12rl0uy/wish/1562152370