Exp 5: Determination of moisture permeability for various containers and closures by Ashok Kumar https://padlet.com/akpharm/x4dwzi5vkw7j How important is this experiment in a storage of pharmaceutical product en-us 2018-04-06 09:04:35 UTC 2018-04-06 14:37:24 UTC hello@padlet.com https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249167543 In short, white plastic bottle with screw cap is the container that resistant to moisture permeation while the transparent plastic bottle is the least effective container in preventing moisture permeation. Thus, the selection of an appropriate container and closure is vital to preserve the integrity of drug content and to provide the protection against mechanical, environmental, biological and chemical hazards. ]]> 2018-04-06 10:37:33 UTC https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249167543 https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249170942 The white plastic bottle is most resistant against moisture (least moisture permeability), followed by amber glass bottle and then transparent plastic bottle. The screw cap is more resistant to moisture than snap on cap. The efficiency of amber glass bottle is higher than transparent glass bottle for all relative humidity.

]]> 2018-04-06 10:56:33 UTC https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249170942 As a conclusion, types of container and closure are important parameters to be considered during packaging in order to maintain the integrity of the products. As the relative humidity of the environment increases, the moisture permeation rate also increases. Too high permeation rate of moisture may accelerate the hydrolysis of drug and thus loss its therapeutic efficacy. Thus, the relative humidity must keep within the recommended range. The amber glass bottle with screw cap is found to be most resistant to moisture penetration compare to white plastic bottle with screw cap and transparent white bottle with insert cap. (Liew Ai Nee) https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249183978 2018-04-06 11:59:39 UTC https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249183978 Ema https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249184862 There are many different types of containers made of different kind of materials. These containers need to have certain characteristics to ensure the quality of the products contained in them is maintained for a reasonable time frame. 

From this experiment, it can be seen that the white plastic bottle is the most effective against moisture permeation, followed by amber glass bottle and transparent plastic bottle while the best storage humidity among 75%, 85% and 96% is found to be 85%. 
In pharmaceutical industry, the knowledge of suitable storage condition for drug is very important to maximize the shelf life. Drug that are improperly stored could either have a decreased efficacy or develop reactions to form toxic precipitate. This would be dangerous to the patients and it could also cause a huge loss to the manufacturer. 

]]> 2018-04-06 12:02:27 UTC https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249184862 https://padlet.com/akpharm/x4dwzi5vkw7j/wish/249244511 This experiment shows that glass bottle with screw cap provides best protection against moisture permeability. The effectiveness of the closure system has a more profound effect on moisture permeability compared to the container itself, whereby, insert cap allow greater moisture permeation compared to screw cap. Thus, plastic bottle with insert caps allow more moisture to permeate in than glass bottle with screw cap. (Eugene

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