immunology PO6 by SRI VISHAALNY JAGANATHAN https://padlet.com/19003116/immunT5PO6 P06 en-us 2020-05-26 01:21:38 UTC 2020-06-02 16:18:48 UTC hello@padlet.com Xin Ru 19004549 https://padlet.com/19003116/immunT5PO6/wish/605958602 1. Central tolerance happens on the primary lymphatic organ- bone marrow (b cell) and thymus (t cell)
2. There are 4 types of transplant rejection; hyperacute, accelerated, acute and chronic. ]]> 2020-06-02 01:37:37 UTC https://padlet.com/19003116/immunT5PO6/wish/605958602 Sri 19003116 https://padlet.com/19003116/immunT5PO6/wish/605959801 positive selection: binds to polymorphic residue of the MHC but does not interact with TCR 

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  • At immune privileged sites (brain, eyes, testis, placenta). There are higher degree of tolerance to antigens. These antigens are not used during negative selection
    •  
    • Sites with immune privilege are anatomical regions that are naturally less subject to immune responses than most other areas of the body.

    ]]>     2020-06-02 02:49:49 UTC https://padlet.com/19003116/immunT5PO6/wish/606019919     wafa https://padlet.com/19003116/immunT5PO6/wish/606154586
  • Immunosuppressant drugs to suppress T cell activation and immune activation in general
    •  
    • Cyclosporin, tacrolimus 
      • Inhibits activation of T cells 
    • Corticosteroids 
      • Suppresses inflammation 
     
     
    DISADVANTAGES:
    • More likely to get infections 
      • Less resistant to infections 
    • Harder to treat infections 

    ]]>     2020-06-02 05:28:57 UTC https://padlet.com/19003116/immunT5PO6/wish/606154586     sri 19003116 https://padlet.com/19003116/immunT5PO6/wish/606196048 immune privileged site e.g includes brain eyes testis and placenta. 
    they can withstand high tolerance of antigens 

    ]]>     2020-06-02 06:07:18 UTC https://padlet.com/19003116/immunT5PO6/wish/606196048     sri 19003116 https://padlet.com/19003116/immunT5PO6/wish/606198537 Treg cells are also called self reactive T cells ]]> 2020-06-02 06:09:22 UTC https://padlet.com/19003116/immunT5PO6/wish/606198537 wafa https://padlet.com/19003116/immunT5PO6/wish/606374437 The state of unresponsiveness of the immune system to antigen is called IMMUNE TOLERANCE 
    • Immune system does not react to an immune response when encounters an antigen
     
    The state of unresponsiveness of the immune system to self-antigens is called SELF-TOLERANCE
    • If this fails, this leads to autoimmunity 
      • Immune system attacks itself 
    • Then resulting into autoimmune diseases 
      • Individual's own molecules, cells, tissues and organs are damaged as a result of immune system attack
    ]]>     2020-06-02 08:06:31 UTC https://padlet.com/19003116/immunT5PO6/wish/606374437     sri 19003116 https://padlet.com/19003116/immunT5PO6/wish/606507224 difference between acute and accelerated 
    acute rejection happens within a short period of time
    accelerated is usually slightly longer but if intro second time then it is more fast ]]>     2020-06-02 09:29:02 UTC https://padlet.com/19003116/immunT5PO6/wish/606507224     Xin Ru 19004549 https://padlet.com/19003116/immunT5PO6/wish/607222037 3. Graft is the tissue or organ that is to be transplanted
    4. Autograph is from the same individual while isograft/syngraft from genetically identical individual like twins]]>     2020-06-02 16:16:17 UTC https://padlet.com/19003116/immunT5PO6/wish/607222037