https://padlet.com/fyeong/M1_carboh Made with mirth en-us 2016-09-13 07:12:53 UTC 2016-09-13 07:43:50 UTC hello@padlet.com fyeong https://padlet.com/fyeong/M1_carboh/wish/123352170 2016-09-13 07:13:54 UTC https://padlet.com/fyeong/M1_carboh/wish/123352170 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352197 2016-09-13 07:14:03 UTC https://padlet.com/fyeong/M1_carboh/wish/123352197 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352204 2016-09-13 07:14:07 UTC https://padlet.com/fyeong/M1_carboh/wish/123352204 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352207 2016-09-13 07:14:09 UTC https://padlet.com/fyeong/M1_carboh/wish/123352207 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352218 2016-09-13 07:14:12 UTC https://padlet.com/fyeong/M1_carboh/wish/123352218 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352226 2016-09-13 07:14:15 UTC https://padlet.com/fyeong/M1_carboh/wish/123352226 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352239 2016-09-13 07:14:18 UTC https://padlet.com/fyeong/M1_carboh/wish/123352239 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352284 2016-09-13 07:14:37 UTC https://padlet.com/fyeong/M1_carboh/wish/123352284 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352306 2016-09-13 07:14:45 UTC https://padlet.com/fyeong/M1_carboh/wish/123352306 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352309 2016-09-13 07:14:48 UTC https://padlet.com/fyeong/M1_carboh/wish/123352309 https://padlet.com/fyeong/M1_carboh/wish/123352365 -Von Gierke
-Glucose-6-Phosphatase deficiency leads to accumulation as it is not converted into glucose
- This explains the hypoglycaemia as product of glycogen degradation does not fully convert to glucose to be used extracellularly
-G6P accumulation inhibits gluconeogenesis leading to accumulation of pyruvate and therefore lactate through anaerobic respiration. This explains the high level of pyruvate and lactate.
-HMP shunt produces uric acid through nucleotide metab.
-accumulation of G6P in liver cells results in accumulation of glycogen therefore organomegaly


]]> 2016-09-13 07:15:13 UTC https://padlet.com/fyeong/M1_carboh/wish/123352365 https://padlet.com/fyeong/M1_carboh/wish/123352485 2016-09-13 07:16:16 UTC https://padlet.com/fyeong/M1_carboh/wish/123352485 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352499 2016-09-13 07:16:24 UTC https://padlet.com/fyeong/M1_carboh/wish/123352499 https://padlet.com/fyeong/M1_carboh/wish/123352527 - HMP Shunt
- Oxidation of glucose-6-phosphate to 6-phosphoglucono-delta-lactone
- Production of NADH]]> 2016-09-13 07:16:34 UTC https://padlet.com/fyeong/M1_carboh/wish/123352527 https://padlet.com/fyeong/M1_carboh/wish/123352531 2016-09-13 07:16:36 UTC https://padlet.com/fyeong/M1_carboh/wish/123352531 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352571 2016-09-13 07:16:57 UTC https://padlet.com/fyeong/M1_carboh/wish/123352571 fyeong https://padlet.com/fyeong/M1_carboh/wish/123352585 2016-09-13 07:17:04 UTC https://padlet.com/fyeong/M1_carboh/wish/123352585 https://padlet.com/fyeong/M1_carboh/wish/123352587 2016-09-13 07:17:04 UTC https://padlet.com/fyeong/M1_carboh/wish/123352587 https://padlet.com/fyeong/M1_carboh/wish/123352681 - Student is G6PD deficient (10-60% of normal activity)
- Antimalarial drugs increase the levels of ROS
- Leads to increased levels of GSSG as GSH levels are depleted to reduce the levels of ROS
- Problem of G6PD deficiency is amplified as there is insufficient G6PD to reduced the increased levels of GSSG
- Consequentially, ROS are not eliminated; oxidise proteins that maintain RBC membrane plasticity, leading to haemolysis]]> 2016-09-13 07:17:53 UTC https://padlet.com/fyeong/M1_carboh/wish/123352681 https://padlet.com/fyeong/M1_carboh/wish/123353119 - In RBCs, G6PD/ NADPH is the only source of reduced glutathione
- Compromises the function of RBCs severely (need to be flexible to effectively transport oxygen throughout body)
- In other organs, NADPH can be produced from other pathways (?)]]> 2016-09-13 07:20:53 UTC https://padlet.com/fyeong/M1_carboh/wish/123353119 https://padlet.com/fyeong/M1_carboh/wish/123353317 Gluconeogenesis and Glycogen metabolism]]> 2016-09-13 07:22:30 UTC https://padlet.com/fyeong/M1_carboh/wish/123353317 https://padlet.com/fyeong/M1_carboh/wish/123353356 Aspirin broken down in the liver and the products formed are hepatotoxic and thus the products kill the hepatocytes in the liver. The liver cells are therefore dysfunctional and  are unable to break down glycogen to glucose, neither can they undergo gluconeogenesis. Hence blood sugar levels are low. 

]]> 2016-09-13 07:22:49 UTC https://padlet.com/fyeong/M1_carboh/wish/123353356 https://padlet.com/fyeong/M1_carboh/wish/123353526 - Depends on the combination of alleles for the G6PD gene in both mother and father
- If male student has, it means that the mother at least has 1 copy of the recessive G6PD deficient allele
- It is unknown if the father has recessive allele on his X-chromosome
- If father has recessive allele, daughter will definitely be a carrier (at least)
- If mother is homozygous recessive, daughter will definitely be a carrier as well (at least)
- Daughter will only have the same problem if father has G6PD deficient allele and mother is homozygous recessive]]> 2016-09-13 07:24:20 UTC https://padlet.com/fyeong/M1_carboh/wish/123353526 https://padlet.com/fyeong/M1_carboh/wish/123353616 No. Liver cells are dead, and would not be able to respond to glucagon.

]]> 2016-09-13 07:24:55 UTC https://padlet.com/fyeong/M1_carboh/wish/123353616 https://padlet.com/fyeong/M1_carboh/wish/123353924 2016-09-13 07:27:30 UTC https://padlet.com/fyeong/M1_carboh/wish/123353924 https://padlet.com/fyeong/M1_carboh/wish/123353984 Sucrose--> fructose=more G6P(gluconeogenesis)
Lactose= galactose=glucose 6 phosphate( through action of galactose 1 p uridyltransferase and phosphoglucose mutase) ]]> 2016-09-13 07:27:48 UTC https://padlet.com/fyeong/M1_carboh/wish/123353984