a377 activity 3 by celeste chua https://padlet.com/celestechua2016/wholoa93flms8h8t en-us 2023-02-03 04:02:09 UTC 2026-01-21 20:30:34 UTC hello@padlet.com Biopharmaceuticals 21025535_2 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467085550 2023-02-03 04:06:02 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467085550 Types of biopharmaceuticals 21025535_2 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467086151 1. Protein-based therapeutics
2. Vaccines
3. Peptide drugs
4. Nucleic acid-based drugs

]]> 2023-02-03 04:06:52 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467086151 Biopharmaceutical manufacturing processes celestechua2016 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467087027 upstream processing: culture and maintenance of cells
downstream processing: chemical + physical separations and purifications from culture mixture]]> 2023-02-03 04:08:05 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467087027 stabilization of proteins https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467088318 - PEGylation
- proteinylaton
- protein sequence modification (site directed mutagenesis)]]> 2023-02-03 04:09:50 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467088318 BSC Workflow https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467089186 - dry waste and liquid waste container (must be able to be capped)
- items must be arranged so that it does not disrupt airflow]]> 2023-02-03 04:10:57 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467089186 packaging and storage of biopharmaceuticals https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467090508 packaging: smooth glass walls, dark opaque walls, air tight container, avoid usage of polystrene with sinlanyl/plasticizer coating
storage: freeze drying in low temp to prevent moisture, refrigeration

]]> 2023-02-03 04:12:55 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467090508 Delivery of Biopharmaceuticals celestechua2016 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467090639 parenteral, inhalation, oral, transdermal, gastrointestinal mucoadhesive patch]]> 2023-02-03 04:13:06 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467090639 Bioreacter 21025535_2 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467092163 Used to culture systems to produce cells/organisms or secondary metabolites.


]]> 2023-02-03 04:15:08 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467092163 cell culture requirements https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467092772 1. pH
2. temperature
3. nutrient supply
4. salt concentration
5. aeration/dissolved oxygen
6.sterility
7. anti-foaming]]> 2023-02-03 04:15:55 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467092772 purification methods https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467093924 2023-02-03 04:17:34 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467093924 purification methods https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094122 - centrifugation
- size exclusion chromatography
- ion exchange chromatography
- protein affinity chromatography]]> 2023-02-03 04:17:51 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094122 disposable bioreactors https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094354 - single-use tool/device
- mostly pre-sterilized
- made of high quality plastic]]> 2023-02-03 04:18:12 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094354 fixed-in-place bioreactors https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094531 - in fixed-in-place, made up of stainless steel or glass]]> 2023-02-03 04:18:29 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467094531 Formulation challenges 21025535_2 https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467115141 1.Large and unstable molecules
2.Easily destroyed by the body
3.Specific storage conditions required 
4.Weak bonds between molecules
5.Hard to obtain in large amounts]]> 2023-02-03 04:47:48 UTC https://padlet.com/celestechua2016/wholoa93flms8h8t/wish/2467115141