A songwriter since the age of 12, he grew up in Puerto Rico, later spending time in New York City before his career took off. In 2014, he signed a record contract and began posting songs online. By 2015, songs such as "Si Tu Marido No Te Quiere" had become radio hits across Latin America. In early 2016, he collaborated DJ Luian, Mambo Kingz, De la Ghetto, Arcángel, and Anuel AA on the track "La Ocasion," which kicked off a modest chart run for the rising artist. Months later, he released a remix of his song "No Quiere Enamorarse," which featured superstar Daddy Yankee. The song racked up millions of streaming views. He followed with "Dile Que Tu Me Quieres," "Si Tu Marido No Te Quiere [Remix]," and "En la Intimidad," all of which charted in the Top 30.

In 2017, he delivered his full-length debut album, Odisea, which featured guest appearances by De la Ghetto, Anuel AA, J Balvin, and others. In September, the album peaked at number one on the Top Latin Albums chart. He also contributed to a handful of collaborations with Daddy Yankee, Wisin, J Balvin, Chris Jeday, and others. One of the most prominent duets was 2018's "La Modelo" with American rapper Cardi B, which marked Ozuna's first entry on the Hot 100. His sophomore effort, Aura, arrived in August 2018.