My brilliant wall by https://padlet.com/qahussein/vmgr9mnq8ziu Made with a creative frenzy en-us 2018-05-02 22:05:03 UTC 2018-05-02 22:25:12 UTC hello@padlet.com Sickle Cell Disease qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257461886 2018-05-02 22:07:33 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257461886 Pathophysiology: Gene Mutation qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462147 The SCA gene mutation causes one of the beta polypeptide chains of Hgb structure to be abnormal  
This changes the normal hemoglobin molecule Hgb A into Hgb S, the major type of Hgb in sickle cell anemia. 
]]> 2018-05-02 22:09:32 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462147 Sickle cell anemia: qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462349  The mutations cause the RBC to be sickled in shape and structural fragility]]> 2018-05-02 22:11:04 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462349 Splenic Sequestration Crisis: qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462668
The shape of the sickle cells makes it more likely for them to get stuck in vessels and organs. Occurs when red blood cells get stuck in the spleen, making it enlarge quickly. Fewer red blood cells are circulating in the blood which leads to anemia. 

]]> 2018-05-02 22:13:34 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462668 Acute Chest Syndrome qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462960 Caused by sickling in the blood vessels of the lungs.  As a result lung tissue are damaged and cannot exchange oxygen. Acute chest syndrome often starts a few days after a painful crisis begins. A lung infection may accompany acute chest syndrome.]]> 2018-05-02 22:15:58 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257462960 Inheritance qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257463084 - Trait: Has one sickle cell trait but not the disease

- Sickle cell disease: has two copies of sickle hemoglobin gene]]> 2018-05-02 22:16:58 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257463084 Example of inheritance of gene qahussein https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257463561
If father and mother both have one copy of the sickle hemoglobin gene, then 2 children will carry sickle trait, one child will have two normal genes, and one child would have sickle cell disease.]]> 2018-05-02 22:20:27 UTC https://padlet.com/qahussein/vmgr9mnq8ziu/wish/257463561