Group 2 - Pharmacology Terms and Definitions by StevenWal https://padlet.com/StevenWal/vkew5quiske8 Let's create a resource to help us all the way through the unit! en-us 2018-02-22 00:14:08 UTC 2018-02-23 03:54:34 UTC hello@padlet.com Tolerance StevenWal https://padlet.com/StevenWal/vkew5quiske8/wish/234563192 Reduced reaction to a drug following repeated use]]> 2018-02-23 03:07:57 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563192 Antagonist: a molecule that binds to a receptor that does not illicit a response https://padlet.com/StevenWal/vkew5quiske8/wish/234563308 2018-02-23 03:08:28 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563308 bioavailability https://padlet.com/StevenWal/vkew5quiske8/wish/234563410 the proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.]]> 2018-02-23 03:09:09 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563410 pKa: the pH at which a drug is 50% ionised and 50% unionised https://padlet.com/StevenWal/vkew5quiske8/wish/234563461 2018-02-23 03:09:28 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563461 https://padlet.com/StevenWal/vkew5quiske8/wish/234563521 Half life: its the time it takes for the body to get half the drug metabolized and out of the body 

]]> 2018-02-23 03:09:55 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563521 Hepatic first pass effect https://padlet.com/StevenWal/vkew5quiske8/wish/234563599 amount of a drug which is metabolised before reaching systemic circulation resulting in reduced bioavailability]]> 2018-02-23 03:10:27 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563599 Tachyphylaxis: quickly reduced response to repeated doses of a drug, causing it to be less effective https://padlet.com/StevenWal/vkew5quiske8/wish/234563664 2018-02-23 03:10:56 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563664 Half life: the time it takes for a drug to reach half of its initial blood plasma concentration https://padlet.com/StevenWal/vkew5quiske8/wish/234563946 2018-02-23 03:12:39 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563946 https://padlet.com/StevenWal/vkew5quiske8/wish/234563989 Pharmacokinetics: the movement and alteration of a drug within a body 
ADME
Absorption, Distribution, Metabolism ,exertion]]> 2018-02-23 03:13:00 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234563989 Pharmacodynamics https://padlet.com/StevenWal/vkew5quiske8/wish/234564199 The effect of a drug on the body: action-effect sequence + dose effect relationship]]> 2018-02-23 03:14:26 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564199 Anaphylaxis https://padlet.com/StevenWal/vkew5quiske8/wish/234564435 an acute allergic reaction to an antigen to which the body has become hypersensitive]]> 2018-02-23 03:16:04 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564435 Drug specificity https://padlet.com/StevenWal/vkew5quiske8/wish/234564439 refers to a drug's ability to preferentially produce a particular effect and is related to the structural specificity of drug binding to receptors.]]> 2018-02-23 03:16:06 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564439 Drug selectivity https://padlet.com/StevenWal/vkew5quiske8/wish/234564515 A property of a drug determined by combining its affinity at various binding sites, the knowledge of which can help predict a drug's potential for therapeutic and side effects.]]> 2018-02-23 03:16:46 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564515 Lipid soluble https://padlet.com/StevenWal/vkew5quiske8/wish/234564618 Capacity of a molecule to pass through a phospholipid bilayer ]]> 2018-02-23 03:17:34 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564618 Tolerance https://padlet.com/StevenWal/vkew5quiske8/wish/234564756 Reduced effect of a drug following repeated use]]> 2018-02-23 03:18:38 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564756 https://padlet.com/StevenWal/vkew5quiske8/wish/234564941 Protein regulatory :Any protein that influences the regions of a DNA molecule that are transcribed by RNA polymerase during the process of transcription. It assist in the production of protein in cells]]> 2018-02-23 03:20:08 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234564941 Clearance https://padlet.com/StevenWal/vkew5quiske8/wish/234565131 How a drug is expelled from the body]]> 2018-02-23 03:21:36 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565131 https://padlet.com/StevenWal/vkew5quiske8/wish/234565211 ion: negatively charged ion ]]> 2018-02-23 03:22:06 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565211 Pharmacotherapeutics https://padlet.com/StevenWal/vkew5quiske8/wish/234565333 The study of theraputic uses and effects of drugs

]]> 2018-02-23 03:23:10 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565333 Prodrug https://padlet.com/StevenWal/vkew5quiske8/wish/234565396 Inactive compound metabolised in body to produce pharmologically active drug

]]> 2018-02-23 03:23:45 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565396 https://padlet.com/StevenWal/vkew5quiske8/wish/234565422 Cation: positively charged ion ]]> 2018-02-23 03:23:52 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565422 Competitive antagonist https://padlet.com/StevenWal/vkew5quiske8/wish/234565935 When antagonistic molecules have to compete with endogenous agonists for receptor binding]]> 2018-02-23 03:28:27 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565935 Partial Agonist https://padlet.com/StevenWal/vkew5quiske8/wish/234565968 drugs that bind to and activate a given receptor, but at a sub-maximal level]]> 2018-02-23 03:28:52 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234565968 https://padlet.com/StevenWal/vkew5quiske8/wish/234566490 pH is a 0-14 measure of hydrogen ion concentration; a measure of the acidity or alkalinity of a solution. 7 is neutral, lower values are more acid and higher values are more alkaline.]]> 2018-02-23 03:33:28 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234566490 PH- https://padlet.com/StevenWal/vkew5quiske8/wish/234566690 Figure expressing acidity or alkalinity of solution]]> 2018-02-23 03:35:15 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234566690 Full agonist: https://padlet.com/StevenWal/vkew5quiske8/wish/234566727 drugs that bind to and activate a given receptor at a maximum level]]> 2018-02-23 03:35:29 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234566727 https://padlet.com/StevenWal/vkew5quiske8/wish/234566952 Plasma protein binding (PPB) 
affects the time that a drug stays in the body and can also have an effect upon the drug's efficiency. ]]> 2018-02-23 03:36:51 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234566952 https://padlet.com/StevenWal/vkew5quiske8/wish/234567228 Inverse agonist is an agent that binds to the same receptor as an agonist, but triggers the opposite pharmacological effect of a receptor agonist.

]]> 2018-02-23 03:39:25 UTC https://padlet.com/StevenWal/vkew5quiske8/wish/234567228 Pharmacogenetics https://padlet.com/StevenWal/vkew5quiske8/wish/234568266 The branch of pharmacology concerned with the effect of genetic factors on

Pharmacogenetics has been defined as the study of variability in drug response due to heredity 

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