KI Rats will undergo a craniotomy under pentobarbitone anaesthesia for implantation of electrodes for later recording (in conscious animals). by Paul Flecknell https://padlet.com/ratvet/KInovember2 The implant will be anchored to the skull with dental cement. The investigator does not propose any post-op analgesia, as he claims that cerebral tissue is not sensitive to pain. en-us 2020-11-10 07:35:29 UTC 2026-02-27 21:31:40 UTC hello@padlet.com https://padlet.net/icons/png/1f400.png I will try and respond to questions ratvet https://padlet.com/ratvet/KInovember2/wish/919585923 2020-11-13 09:27:41 UTC https://padlet.com/ratvet/KInovember2/wish/919585923 local anaesthesia e.g. lidocaine before incision https://padlet.com/ratvet/KInovember2/wish/919589222 2020-11-13 09:30:01 UTC https://padlet.com/ratvet/KInovember2/wish/919589222 it is an invasive procedure, he will need to make an incision and cut through the skull. The rat will need post-op analgesia and care https://padlet.com/ratvet/KInovember2/wish/919589985 2020-11-13 09:30:32 UTC https://padlet.com/ratvet/KInovember2/wish/919589985 anaesthesia considerations https://padlet.com/ratvet/KInovember2/wish/919590208 2020-11-13 09:30:41 UTC https://padlet.com/ratvet/KInovember2/wish/919590208 analgesic https://padlet.com/ratvet/KInovember2/wish/919590679 2020-11-13 09:30:59 UTC https://padlet.com/ratvet/KInovember2/wish/919590679 https://padlet.com/ratvet/KInovember2/wish/919590925 Local anestesia. Xylocaine in soft tissues]]> 2020-11-13 09:31:11 UTC https://padlet.com/ratvet/KInovember2/wish/919590925 Is pentobarbitone the best option for general anaesthesia in this procedure? https://padlet.com/ratvet/KInovember2/wish/919590933 2020-11-13 09:31:11 UTC https://padlet.com/ratvet/KInovember2/wish/919590933 how long is the procedure? https://padlet.com/ratvet/KInovember2/wish/919591829 About 60-90 minutes

]]> 2020-11-13 09:31:50 UTC https://padlet.com/ratvet/KInovember2/wish/919591829 Post-op care remains important for general well-being, after-effects of the anaesthesia and bone surface/skin are sensitive to pain. https://padlet.com/ratvet/KInovember2/wish/919591863 2020-11-13 09:31:52 UTC https://padlet.com/ratvet/KInovember2/wish/919591863 Post/op analgesia is needed. https://padlet.com/ratvet/KInovember2/wish/919592793 2020-11-13 09:32:35 UTC https://padlet.com/ratvet/KInovember2/wish/919592793 will the rat pull the implant out? https://padlet.com/ratvet/KInovember2/wish/919593118 No

]]> 2020-11-13 09:32:50 UTC https://padlet.com/ratvet/KInovember2/wish/919593118 Will the rat cages alone post/op!! https://padlet.com/ratvet/KInovember2/wish/919593432 the investigator says so - do you agree?

no]]> 2020-11-13 09:33:04 UTC https://padlet.com/ratvet/KInovember2/wish/919593432 NSAIDs can be used post-op https://padlet.com/ratvet/KInovember2/wish/919593894 2020-11-13 09:33:23 UTC https://padlet.com/ratvet/KInovember2/wish/919593894 Although cerebral tissue is not sensitive to pain, cutting the skull tissue induces pain. https://padlet.com/ratvet/KInovember2/wish/919594059 2020-11-13 09:33:31 UTC https://padlet.com/ratvet/KInovember2/wish/919594059 Correct tools, https://padlet.com/ratvet/KInovember2/wish/919595515 clean/sterile conditions,
monitor breathing/heart rate/temperature
eye gel
heating pad
give oxygen
pulse oxy]]> 2020-11-13 09:34:22 UTC https://padlet.com/ratvet/KInovember2/wish/919595515 Monitor animals during surgery! https://padlet.com/ratvet/KInovember2/wish/919596265 2020-11-13 09:34:53 UTC https://padlet.com/ratvet/KInovember2/wish/919596265 will the implant leave an open wound on the skin for the connector? https://padlet.com/ratvet/KInovember2/wish/919597778 if so the rats need to be monitored for infection.

maybe depends on how long the post-op will last]]> 2020-11-13 09:35:57 UTC https://padlet.com/ratvet/KInovember2/wish/919597778 Post-op antibiotics! https://padlet.com/ratvet/KInovember2/wish/919599366 2020-11-13 09:37:04 UTC https://padlet.com/ratvet/KInovember2/wish/919599366 https://padlet.com/ratvet/KInovember2/wish/919599682 Add some topical antibiotics for the incision???]]> 2020-11-13 09:37:17 UTC https://padlet.com/ratvet/KInovember2/wish/919599682 Health monitoring before/after surgery https://padlet.com/ratvet/KInovember2/wish/919599871 Consider age/sex/strain]]> 2020-11-13 09:37:24 UTC https://padlet.com/ratvet/KInovember2/wish/919599871 How long the implants will be inside the brain? https://padlet.com/ratvet/KInovember2/wish/919601476 For 3 months

]]> 2020-11-13 09:38:32 UTC https://padlet.com/ratvet/KInovember2/wish/919601476 Duration of anaesthesia should be long enough to complete the surgery; place catheter in tail vein if needed to give an additional dose/fluids for rehydration https://padlet.com/ratvet/KInovember2/wish/919604339 2020-11-13 09:40:28 UTC https://padlet.com/ratvet/KInovember2/wish/919604339 Probably apply some EMLA in the incision https://padlet.com/ratvet/KInovember2/wish/919605831 2020-11-13 09:41:27 UTC https://padlet.com/ratvet/KInovember2/wish/919605831 Pentobarbitone or Pentobarbital? https://padlet.com/ratvet/KInovember2/wish/919609096 2020-11-13 09:43:38 UTC https://padlet.com/ratvet/KInovember2/wish/919609096 Liquid, glucose as post-op care! https://padlet.com/ratvet/KInovember2/wish/919612763 2020-11-13 09:46:37 UTC https://padlet.com/ratvet/KInovember2/wish/919612763