A233 Lesson 8 Recap by Chan Yu Tong https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx Made with magic en-us 2020-07-20 01:21:52 UTC 2020-07-20 01:43:08 UTC hello@padlet.com Haqim 190286861 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990374 Chronic obstructive pulmonary disease (COPD) is a common, chronic and preventable respiratory disease]]> 2020-07-20 01:23:03 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990374 Zhiyan zhiyannch https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990465 Antimuscarinic 
SAMA: ipratropium
LAMA: tiotropium ]]> 2020-07-20 01:23:08 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990465 SABA https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990501 LABA
beta 2 agonists
-sean]]> 2020-07-20 01:23:11 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990501 Nurul nurulainfatehah2609 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990533 Beta2 agonists:
- SABA (short-acting)
- LABA (Long-acting)

]]> 2020-07-20 01:23:12 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990533 Celeste https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990597 Asthma is a chronic disease caused by the reversible narrowing of the airways in the lungs, resulting in irritation, inflammation, and difficulty breathing. Possible risk factors of asthma: Smoking and family history ]]> 2020-07-20 01:23:16 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990597 Yan Ting tingyy https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990761 Symptoms of asthma:
- Wheezing: High pitched wheezing sound that is caused by airflow turbulence
- Coughing: Usually non productive
- Shortness of breath 
- Chest tightness / pain]]> 2020-07-20 01:23:29 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990761 Keng Yao https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990788 SABA--> symptomatic relief for asthma]]> 2020-07-20 01:23:31 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990788 raudhah 19000963_ https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990795 Controller: prevent attacks (long acting)
Relievers: for symptomatic relief of attacks
3 Pharmacological class:
bronchodilator: 
- anti muscarinic: SAMA, LAMA
- b2 agonist: LABA, SABA
anti-inflammatory: 
- corticosteroid
both:
- leukotrienes receptor antagonist
- xanthine derivatives]]> 2020-07-20 01:23:31 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990795 jannah jannahbanana991 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990933 corticosteroids
- targets gene transcription
- agonistic interactions with GR
- GC/GR complex enhance anti-inflammatory effects and inhibits proinflammatory mediator production
E.G. Beclomethasone, Budesonide, Fluticasone, Prednisolone]]> 2020-07-20 01:23:41 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657990933 Nadiyah https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991200 SABA - Reliever
Controller (long-acting)- LABA, SAMA, 


]]> 2020-07-20 01:24:00 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991200 Ethan 190127661 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991243 Pathophysiology of  Asthma:
- Increased mucus production
- Bronchoconstriction
- Airway Inflammation

Pathophysiology of COPD: 
COPD Leads to:
Emphysema
Small airway fibrosis 

which eventually leads to
- Ineffective gaseous exchange
- Progressive Airflow limitation]]> 2020-07-20 01:24:03 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991243 Solehah solehaha2222 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991263 (Preventors)
LABA - Bronchodilator
Xanthin derivatives - Bronchodilator/Anti-inflammation
LTRA - Bronchodilator/anti-inflammation
Corticosteroids - Anti-inflammation

]]> 2020-07-20 01:24:04 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991263 xin yi https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991329 Beta-2 agonist (bronchodilator)
- salbutamol (SABA)
- salmeterol (LABA)

Anti-muscarinic (bronchodilator) 
- Ipratropium (SAMA)
- Tiotropium (LAMA)

Corticosteroids (anti-inflammatory)
- budesonide 

]]> 2020-07-20 01:24:10 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991329 sean https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991591 corticosteroids

]]> 2020-07-20 01:24:26 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991591 JinG YU https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991936 Anti-muscrinic  
SAMA 
LAMA 
Used in combination therapy with beta- agonist 

]]> 2020-07-20 01:24:51 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657991936 sean https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657992233 xanthane derivatives

]]> 2020-07-20 01:25:16 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657992233 Haqim 190286861 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657992550 Symptoms if COPD:
- Coughing
    -May be productive or unproductive
      -Chronic and persistent

- Sputum production
-Result of mucus and exudate production

-Wheezing and Chest tightness / pain
      -Can vary between patients and frequency
]]> 2020-07-20 01:25:37 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657992550 Nabihah elantrica09 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993072 Beta 2 agonists
- SABA (short acting beta 2 agonist)
    - used as relievers of acute attacks
- LABA (long acting beta 2 agonist)
- used as controllers to prevent attacks]]> 2020-07-20 01:26:14 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993072 Yi Fan https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993208 Leukotriene receptor antagonists

]]> 2020-07-20 01:26:25 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993208 xiner https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993232 COPD - a chronic and preventable respiratory disease]]> 2020-07-20 01:26:26 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993232 Mengyong https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993316 Bronchodilator: Beta 2 agonist, anti muscarinics
Anti-inflammatory: corticosteroids
Both: xanthine derivatives, Leukotriene receptor antagonists

]]> 2020-07-20 01:26:31 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993316 Asthma nicolegay88 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993517 Increased sensitivity to irritants and stimuli that cause airways to be constricted.
Results in:
- Airway inflammation
- Bronchoconstriction
- Increases mucus membrane]]> 2020-07-20 01:26:44 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657993517 jeanelle https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994001 MOA of beta-2 agonist: activation of beta 2 adrenergic receptors in bronchial smooth muscle, results in direct relaxation of airway smooth muscles, causing bronchodilation ]]> 2020-07-20 01:27:15 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994001 dina ssyahdina https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994330 corticosteroids:
- commonly admistered directly into airway via inhalation
- reduced adverse effects as systemic absorption is minimised]]> 2020-07-20 01:27:39 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994330 Symptoms of COPD nuraisyah4114 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994418 Difficulty in breathing(dyspnea)
Coughing
Sputum production
wheezing and chest tightness

]]> 2020-07-20 01:27:45 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994418 Zareef zareefluqman https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994778 Symptoms of Asthma
-Wheezing
-Coughing
-Shortness of breath
-Chest pain/tightness

Symptoms of COPD
-Difficulty of breathing (Dypsnea)
-Coughing
-Sputum production
-Wheezing and chest pain/tightness

]]> 2020-07-20 01:28:11 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657994778 190213201 https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657996982 Combination therapy consist of anti-muscarinic and beta-2 agonists have shown to be useful (to relieve acute symptoms). Results in slightly greater and more prolonged bronchodilation than with either agent alone (synergistic effect)

]]> 2020-07-20 01:31:05 UTC https://padlet.com/yvonneyvonneyvonne/v2cuw7q9rfd0f0hx/wish/657996982