Omeprazole by https://padlet.com/jlederer19/omeprazole en-us 2022-04-09 17:52:45 UTC 2022-04-15 13:29:01 UTC hello@padlet.com Omeprazole (Prilosec) premscke8115 https://padlet.com/jlederer19/omeprazole/wish/2137524607 Class: Proton Pump Inhibitor and Antisecretory ]]> 2022-04-09 17:58:52 UTC https://padlet.com/jlederer19/omeprazole/wish/2137524607 Pharmacologic Actions jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137525321 - An antisecretory compound that is a gastric acid pump inhibitor 
- Suppresses gastric acid secretion by inhibiting the H+K+ ATPase enzyme system in the parietal cells ]]> 2022-04-09 18:00:18 UTC https://padlet.com/jlederer19/omeprazole/wish/2137525321 Therapeutic Uses jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137525564 - Short-term treatment of gastric/duodenal ulcers
 - Prophylaxis of recurrent duodenal ulcers
 - Treatment of Zollinger-Ellison syndrome and hypersecretory states
 - Treatment of GERD
- OTC – to treat heartburn, acid indigestion, sour stomach
]]> 2022-04-09 18:00:46 UTC https://padlet.com/jlederer19/omeprazole/wish/2137525564 Pharmacokinetic Properties jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137525709 Absorption: poorly absorbed from GI tract
Distribution: 30-40% reaches systemic circulation
Metabolism: metabolized by liver
Elimination: 80% in urine, 20% in feces
Onset: 0.5-3.5 hr
Peak: peak inhibition of gastric acid secretion is 5 days
Half-life: 0.5-1.5 hr]]> 2022-04-09 18:01:02 UTC https://padlet.com/jlederer19/omeprazole/wish/2137525709 Adverse Effects jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137525913 Fractures 
Headache
Hypomagnesemia
Pneumonia 
Acid Rebound 
Diarrhea (may be associated with C-diff)]]> 2022-04-09 18:01:28 UTC https://padlet.com/jlederer19/omeprazole/wish/2137525913 Drug Interactions jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137525952 Atazanavir, Delavirdine, and Nelfinavir: PPIs significantly reduce absorption of these drugs, which are used to treat HIV/AIDS
Clopidogrel: PPIs and clopidogrel should be combined in patients with risk of GI bleeding but should be avoided in patients who lack risk factors
Food: can decrease absorption by up to 35%]]> 2022-04-09 18:01:33 UTC https://padlet.com/jlederer19/omeprazole/wish/2137525952 Contraindications/Precautions jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137526020 Use cautiously: with dysphagia, pregnancy, lactation, and in pediatrics  ]]> 2022-04-09 18:01:41 UTC https://padlet.com/jlederer19/omeprazole/wish/2137526020 Patient Teaching jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137526068 - Encourage patient to eat 5 or 6 small meals per day instead of 3 larger meals
- Avoid smoking, alcohol, aspirin, and other NSAIDs if trigger]]> 2022-04-09 18:01:48 UTC https://padlet.com/jlederer19/omeprazole/wish/2137526068 Nursing Implications/Diagnoses jlederer19 https://padlet.com/jlederer19/omeprazole/wish/2137526150 - Monitor for and report lack of improvement or worsening GI symptoms
- Monitor magnesium levels 
- Evaluate bone density test with long-term use ]]> 2022-04-09 18:01:58 UTC https://padlet.com/jlederer19/omeprazole/wish/2137526150