•Advances in scientific understanding in one field can influence and be influenced by other areas of science, technology, engineering, and mathematics.

•The acceptance and use of scientific knowledge can be influenced by social, economic, cultural, and ethical considerations. 

•The use of scientific knowledge may have beneficial or unexpected consequences; this requires monitoring, assessment, and evaluation of risk, and provides opportunities for innovation. 

•International collaboration is often required in scientific investigation.

•Development of complex scientific models and/or theories often requires a wide range of evidence from many sources and across disciplines. 

•New technologies improve the efficiency of scientific procedures and data collection and analysis. This can reveal new evidence that may modify or replace models, theories, and processes.