https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6 en-us 2023-09-30 19:09:16 UTC 2023-10-12 15:56:26 UTC hello@padlet.com BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727095483 Huntington disease is caused by a mutation in the gene for a protein called huntingtin. This defect causes the DNA amino acids cytosine, adenine, an guanine to abnormally repeat, causing an expanded hHtt protein. Most people have fewer than 27 CAG repeats in their HD gene, so they are not at risk for the disease (NIH).]]> 2023-09-30 19:23:43 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727095483 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727098256 HD is an autosomal dominant disorder, which means one you need one copy of the non typical gene to be inherited. Each child has a 50% chance of inheriting a copy of chromosome 4 that carries the HD mutation (Mayo).]]> 2023-09-30 19:29:57 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727098256 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727102075

]]> 2023-09-30 19:39:18 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727102075 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727102302 2023-09-30 19:39:50 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727102302 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727104203 Huntington disease affects an estimated 3 to 7 per 100,000 people of European ancestry. The disorder appears to be less common in some other populations, including people of Japanese, Chinese, and African descent (MedlinePlus). ]]> 2023-09-30 19:44:28 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727104203 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727104580 2023-09-30 19:45:31 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727104580 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727108985 There is currently no cure for Huntington's Disease. However, there are treatments to alleviate symptoms such as:

• Medications to lessen the mental and physical effects of the disease like anti psychotics to control hallucinations, delusions, and violent outbursts.
• Therapy for depression and anxiety.
• Physical therapies to help movement problems.

]]> 2023-09-30 19:56:07 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2727108985 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734483316 The most effective and accurate method of testing for Huntington disease—called the direct genetic test—counts the number of CAG repeats in the Huntington gene, using DNA taken from a blood sample. The presence of 36 or more repeats supports a diagnosis of Huntington disease . A test result of 26 or fewer repeats rules out Huntington's Disease (NIH) . 
      Testing for Huntington disease informs the family if they are at risk of developing it later on in life. However, many choose to not know until symptoms appear. ]]> 2023-10-05 19:11:36 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734483316 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734485652 2023-10-05 19:13:39 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734485652 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734498837 It was first hypothesized that Huntington disease is caused by a misfolded huntingtin protein interrupting the neurological functioning of the brain due to a amplification of adenosine-guanine chain in the huntingtin's amino terminal end. However. studies have recently shown that opposed to this first believed hypothesis, that change in the mRNA of the protein gives rise to misfolded protein and the fragments accumulate, by making interaction with the other elements in cells resulting in the problems associated with HD. This experiment highlights the possible cause, pathogenesis, and therapy treatments that can reduce and down-regulate the expression of huntingtin, lowering the aggregation of the huntingtin protein.]]> 2023-10-05 19:26:26 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734498837 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734500542 2023-10-05 19:28:10 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734500542 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734504149 RNA-targeting CRISPR–Cas13d system has shown to improve motor coordination, attenuated striatal atrophy, and reduction of mutant HTT protein aggregates in patients with no adverse effects and minimal off-target transcriptomic effects. Demonstrating a therapeutic approach for HD, and a strategy with implications for the treatment of other dominantly inherited disorders. ]]> 2023-10-05 19:31:54 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734504149 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734505268 2023-10-05 19:33:05 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734505268 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734505645 2023-10-05 19:33:29 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2734505645 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2743875437 Huntington's disease is a condition that damages nerve cells in the brain causing them to stop proper functioning. This incapacitates patients by affecting their ability to move, think, and behave normally. ]]> 2023-10-12 15:52:35 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2743875437 BIO100NS https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2743880852 Due to lack of community knowledge on Huntington's disease, suffers of the disease may experience discrimination, ignorance, and social isolation. Leading to depression, anxiety, and an overall degradation of life. ]]> 2023-10-12 15:56:13 UTC https://padlet.com/BIO100NS/tgdarm3rc3kt4ru6/wish/2743880852