Hemochromatosis by Kayla Dutton Leyba https://padlet.com/s81388/tdci9n65jx42 Made with whimsy en-us 2019-03-08 21:18:31 UTC 2019-05-15 19:59:36 UTC hello@padlet.com frequency s81388 https://padlet.com/s81388/tdci9n65jx42/wish/341802373 Type 1 hemochromatosis is one of the most common genetic disorders in the United States, affecting about 1 million people. It most often affects people of Northern European descent. The other types of hemochromatosis are considered rare and have been studied in only a small number of families worldwide.


]]> 2019-03-15 15:19:23 UTC https://padlet.com/s81388/tdci9n65jx42/wish/341802373 Inheritance pattern s81388 https://padlet.com/s81388/tdci9n65jx42/wish/341803550 1, 2, and 3 hemochromatoses are inherited in an a autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene but do not show signs and symptoms of the condition.
Type 4 hemochromatosis is distinguished by its autosomal dominant inheritance pattern. With this type of inheritance, one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition.


]]> 2019-03-15 15:21:38 UTC https://padlet.com/s81388/tdci9n65jx42/wish/341803550 story s81388 https://padlet.com/s81388/tdci9n65jx42/wish/345885426 https://www.toomuchiron.ca/iron-chronicles/samantha/]]> 2019-03-27 20:00:24 UTC https://padlet.com/s81388/tdci9n65jx42/wish/345885426 DESCRIPTION s81388 https://padlet.com/s81388/tdci9n65jx42/wish/350481454 Hereditary hemochromatosis is a disorder that causes the body to absorb too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs.  The appearance and severity of symptoms can be affected by environmental and lifestyle factors such as the amount of iron in the diet, alcohol use, and infections.


]]> 2019-04-10 17:48:06 UTC https://padlet.com/s81388/tdci9n65jx42/wish/350481454 DESCRIPTION s81388 https://padlet.com/s81388/tdci9n65jx42/wish/350482397 There are four types of hereditary hemochromatosis, which are classified depending on the age of onset and other factors such as genetic cause and mode of inheritance.

Type 1, the most common form of the disorder, and type 4 (also called ferroportin disease) begin in adulthood. 
]]> 2019-04-10 17:49:53 UTC https://padlet.com/s81388/tdci9n65jx42/wish/350482397 CAUSES s81388 https://padlet.com/s81388/tdci9n65jx42/wish/350483226 Mutations in several genes can cause hereditary hemochromatosis. Type 1 hemochromatosis results from mutations in the HFE gene, and type 2 hemochromatosis results from mutations in either the HJV or HAMP gene. Mutations in the TFR2 gene cause type 3 hemochromatosis, and mutations in the SLC40A1 gene cause type 4 hemochromatosis.
As a result, iron accumulates in tissues and organs, which can disrupt their normal functions.



]]> 2019-04-10 17:51:21 UTC https://padlet.com/s81388/tdci9n65jx42/wish/350483226 s81388 https://padlet.com/s81388/tdci9n65jx42/wish/350486420 2019-04-10 17:57:07 UTC https://padlet.com/s81388/tdci9n65jx42/wish/350486420