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      <title>Problemas tecnológicos de los comprimidos by Emil Lopez</title>
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      <pubDate>2024-12-04 03:14:52 UTC</pubDate>
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         <description><![CDATA[<p>La variación en el peso de los comprimidos puede afectar la dosificación precisa de los ingredientes activos, generalmente causada por una distribución desigual del granulado en la máquina de compresión.</p>]]></description>
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         <pubDate>2024-12-04 03:50:23 UTC</pubDate>
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         <description><![CDATA[<p>Este problema ocurre cuando la cantidad de principio activo en el comprimido no cumple con los límites establecidos por las farmacopeas. Puede deberse a mezclas insuficientemente homogéneas o procesos de fabricación mal controlados.</p>]]></description>
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         <pubDate>2024-12-04 03:59:02 UTC</pubDate>
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         <description><![CDATA[<p>Los comprimidos con alta friabilidad se desmoronan fácilmente durante el transporte o manejo. Este problema está relacionado con formulaciones débiles o presiones de compresión inadecuadas.</p><p><br></p>]]></description>
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         <description><![CDATA[<p>La dureza afecta tanto la resistencia mecánica como la velocidad de disolución de los comprimidos. Una dureza excesiva dificulta la desintegración, mientras que una dureza baja reduce la estabilidad física.</p><p><br></p>]]></description>
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         <pubDate>2024-12-04 04:00:29 UTC</pubDate>
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         <description><![CDATA[<p>Esto afecta la liberación del principio activo, relacionado con problemas en la elección o cantidad de desintegrantes en la formulación.</p><p><br></p>]]></description>
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         <pubDate>2024-12-04 04:01:02 UTC</pubDate>
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         <description><![CDATA[<p>Indica que el fármaco no se libera adecuadamente en el medio. Este problema puede estar asociado con el uso de excipientes incorrectos, problemas de dureza o defectos en la fabricación.</p>]]></description>
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         <pubDate>2024-12-04 04:03:11 UTC</pubDate>
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         <description><![CDATA[<p>Ocurren cuando partes del comprimido se desprenden durante la compresión o después de ella. Estas fallas suelen deberse a problemas en la formulación, como exceso de humedad, o a la presión inadecuada de las máquinas.</p>]]></description>
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         <pubDate>2024-12-04 04:03:51 UTC</pubDate>
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         <description><![CDATA[<p>El moteado es la aparición de manchas en el comprimido, generalmente debido a la migración de colorantes o a reacciones químicas entre los excipientes y el principio activo.</p><p><br></p>]]></description>
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         <pubDate>2024-12-04 04:06:24 UTC</pubDate>
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         <description><![CDATA[<p>Este problema ocurre cuando el material del comprimido se adhiere a las superficies de las punzonadoras, debido a humedad excesiva o falta de lubricación adecuada.</p>]]></description>
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         <description><![CDATA[<p>Aulton ME, Taylor KMG. Aulton's Pharmaceutics: The Design and Manufacture of Medicines. 5th ed. Edinburgh: Churchill Livingstone; 2018.<br>Allen LV, Popovich NG, Ansel HC. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 11th ed. Philadelphia: Lippincott Williams &amp; Wilkins; 2020.<br>Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 8th ed. London: Pharmaceutical Press; 2017.<br>Mollah AH, Basak SC. Problems in tablet manufacturing: a review. Int J Pharm Sci Rev Res. 2015<br>Gupta R, Gandhi K. Factors affecting tablet compression: a review. World J Pharm Res. 2018</p>]]></description>
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         <description><![CDATA[<p><a rel="noopener noreferrer nofollow" href="http://1.la">la</a> industria farmacéutica” Imprenta Romargraf. Barcelona mayo SM “calidad TSA a. PROBLEMAS TECNOLÓGICOS EN LA [Internet]. <a rel="noopener noreferrer nofollow" href="http://Diposit.ub.edu">Diposit.ub.edu</a>. [cited 2024 Dec 5]. Available from: <a rel="noopener noreferrer nofollow" href="https://diposit.ub.edu/dspace/bitstream/2445/68462/6/libro%20Dr.Salazar%20con%20registro%20UB-VF1%20%20%2020-01-16.pdf">https://diposit.ub.edu/dspace/bitstream/2445/68462/6/libro%20Dr.Salazar%20con%20registro%20UB-VF1%20%20%2020-01-16.pdf</a></p><p><br></p>]]></description>
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