https://padlet.com/emcheng/sx6csbydpyyhqx7 Post a 1-2 sentence summary describing the finding of your figure en-us 2022-02-23 05:50:47 UTC 2025-11-06 04:11:56 UTC hello@padlet.com https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064725847 Each region has a different SETD2 mutation that affects methylation levels, each region has altered methylation levels. WT is the most methylated. ]]> 2022-02-24 15:05:01 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064725847 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064726859 Patient 2- measuring the tumor at 6 weeks for the mutations R 3,6,9,7,1,4 have decreasing shared region in that order. At 15 weeks they measured the metastatic region has very little shared region, showing that within the tumor it is heterogeneous.]]> 2022-02-24 15:05:33 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064726859 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064727133 Sup. Figure 14 
Figure A is showing methylation stays between WT and patient 4. Figure B shows the frame shift mutation in patient 4.

]]> 2022-02-24 15:05:42 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064727133 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729244 Figure 11 demonstrates the allelic imbalances between chromosomes in patients 1-3, and in chromosome 3 that contains VHL and SETD2 which means that the patents (especially 4) have unregulated cell growth and cannot control DNA repair ]]> 2022-02-24 15:06:45 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729244 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729505 In the PTEN mutated biopsy regions there is progressively increased staining of phospho-Akt]]> 2022-02-24 15:06:54 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729505 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729854 Figure A
-Comparing and contrasting primary tumor sites and metastatic sites through the lens of Allelic Imbalance. 

Figure B
-Figure B (Manhattan Plot) is looking at Chromosome 3p and describing intensities of various genes]]> 2022-02-24 15:07:02 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064729854 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064730137 Trimethylated h3k36 showed lower levels in cancer cells but was present in most stromal cells and in Setd2 WT carcinoma]]> 2022-02-24 15:07:10 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064730137 https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064731906 This figure is showing strong LOH localized within the regions of the VHL and SETD2 genes.]]> 2022-02-24 15:07:57 UTC https://padlet.com/emcheng/sx6csbydpyyhqx7/wish/2064731906