ANS by Carlie Lambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k HPRS 2300 Fall 2020 en-us 2020-10-15 05:11:03 UTC 2025-12-31 18:20:46 UTC hello@padlet.com https://padlet.net/icons/png/1f9e0.png carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831158284 2020-10-15 05:18:26 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831158284 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831190418 2020-10-15 05:35:42 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831190418 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831222882 2020-10-15 05:52:08 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831222882 Sympathetic Division carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831237596 Also known as the adrenergic system, the Sympathetic division of the ANS is responsible for the "Fight, Flight, or Fright" responses]]> 2020-10-15 05:59:20 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831237596 Parasympathetic Division carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831246583 Also known as the cholinergic system, the Parasympathetic division is responsible for the "rest and digest" responses]]> 2020-10-15 06:03:41 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/831246583 Neurotransmitters carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834213050
  • Acetylcholine (ACH) - 
    • Released at the ganglia from presynaptic nerve endings
    • Produced by cholinergic neurons

    • ]]>     2020-10-15 23:21:15 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834213050     Dopamine (DA) carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834213439
  • Precursor to NE
  • Stimulates alpha, beta, and dopaminergic receptors
  • Produced by the hypothalamus 

    • ]]>     2020-10-15 23:21:33 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834213439     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834229232 2020-10-15 23:32:44 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834229232 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834229452 2020-10-15 23:32:51 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834229452 Epinephrine (EPI) carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834364505
  • Released from the adrenal medulla
  • Acts on adrenergic receptors
    • ]]>     2020-10-16 00:50:48 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834364505     Norepinephrine (NE) carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834366648
  • Released at postganglionic nerve ending
  • Released by the adrenal medulla and neurons
  • Synthesized from dopamine 

    • ]]>     2020-10-16 00:51:48 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834366648     End Organ Responses carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834418642
  • muscarinic
    • decrease heart rate, bronchoconstriction, increase digestion, increase GI secretions, and increase urination, and pupillary constriction
  • nicotinic 1 (Nn)
  • nicotinic 2 (Nm)
    • If stimulated, muscle contracts
    • ALL are stimulated by ACH


    ]]>     2020-10-16 01:16:37 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834418642     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834425903 2020-10-16 01:20:10 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834425903 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834427761 2020-10-16 01:21:05 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834427761 End Organ Responses carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834430287
  • Alpha 1
    • Organs effected: most arteries and veins, eyes
    • EPI/ NE Response: vasoconstriction and contraction resulting in pupillary dilation
  • Alpha 2
    • Organs effected: Adrenergic nerve ending
    • EPI/ NE Response: Decrease release of NE
  • Beta 1
    • Organs effected: Heart
    • EPI Response: Increase in heart rate, increase in force of contraction, and increase in atrioventricular conduction
    • NE Response: Increase in heart rate, increase in force of contraction, and increase in atrioventricular conduction (not as much of an increase as EPI)
  • Beta 2
    • Organs effected: bronchodilator smooth muscle, uterus, coronary and skeletal blood vessels
    • EPI Response: Bronchodilation, relaxation, and vasodilation
    • NE Response: Norepinephrine does not stimulate B2 responses
    • ]]>     2020-10-16 01:22:12 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834430287     Specific Drug Examples carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834431382
  • Alpha-1 Adrenergic Agonists
    • Ex/ phenylephrine (Neo-Synephrine®)
  • Adrenergic Agonists
    • Ex/ epinephrine (Adrenalin®)
  • Alpha-1 Adrenergic Blocker
    • Ex/ terazosin (Hytrin®)
  • Beta-1 Adrenergic Agonist 
    • Ex/ dobutamine
  • Beta-2 Adrenergic Agonist
    • Ex/ terbutaline (Brethine®)
  • Beta Blocker
    • Nonselective ex/ nadolol (Corgard®)
    • Selective ex/ atenolol (Tenormin®)


    • ]]>     2020-10-16 01:22:44 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834431382     Receptors carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834513273
  • Alpha 1:
    • Locations: glands, smooth muscles, eyes, and most arteries and veins
  • Alpha 2:
    • Negative feedback loop of alpha 1 
  • Beta 1:
    • Located in the heart
  • Beta 2:
    • Located on smooth muscle, lungs, uterus, skeletal muscle blood arteries, and coronary arteries

    • ]]>     2020-10-16 02:04:47 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834513273     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834536174 2020-10-16 02:17:00 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834536174 Drug Classifications carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834555061
  • Alpha-1 Adrenergic Agonists
    • Alpha 1 is stimulated
  • Adrenergic Agonists
    • Stimulates all alpha and beta receptors
  • Alpha-1 Adrenergic Blocker
    • Binds to alpha receptors and blocks them
  • Beta-1 Adrenergic Agonist
    • Low dose: Stimulates D1 receptors in the kidneys causing vasodilation, increased blood flow
    • Mod. dose: Stimulates B1  - increases force of contraction and cardiac output
    • High dose: stimulates A1 receptors causing vasoconstriction and consequently an increase in blood pressure
  • Beta-2 Adrenergic Agonist
    • Stimulates B2 receptors 
  • Beta Blocker
    • Selective: B1 receptor is blocked
  • Nonselective: B1 and B2 receptors are blocked
    • ]]>     2020-10-16 02:27:05 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834555061     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834588114 2020-10-16 02:45:32 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834588114 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834614324 2020-10-16 03:01:13 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834614324 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834616125 2020-10-16 03:02:23 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834616125 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834616543 2020-10-16 03:02:37 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834616543 All stimulated by ACH carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834617799
  • muscarinic
    • Located on the cardiac, smooth muscle and glands
  • nicotinic 1 (Nn)
    • Located at the ganglia of parasympathetic nerves and sympathetic nerves (synapse)
  • nicotinic 2 (Nm)
    • Located at the somatic, neuromuscular junction of skeletal muscle
    • ]]>     2020-10-16 03:03:29 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834617799     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834638261
  • Direct - Acting Cholinergic Agonists
    • stimulates muscarinic receptors
    • mimics ACH
  • Indirect - Acting Cholinergic Agonists
    • inhibits acetylcholinesterase which destroys ACH  at the synapse
    • increases ACH present
  • Anticholinergic 
    • binds to the cholinergic receptor and blocks
    • competitive antagonism 
    • ]]>     2020-10-16 03:16:27 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834638261     carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834648602 2020-10-16 03:23:00 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834648602 carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834649529
  • Direct – Acting Cholinergic Agonists
    • Ex/ Pilocarpine (Pilocar®)
  • Indirect – Acting Cholinergic Agents
    • Ex/ Neostigmine (Prostigmin®)
  • Anticholinergic
    • Ex/ Dicyclomine (Bentyl®)


    • ]]>     2020-10-16 03:23:34 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834649529     Sources carlielambert https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834711545 I used the lecture notes, videos, and textbook from HPRS 2300 Fall 2020 to complete this padlet.]]> 2020-10-16 04:06:37 UTC https://padlet.com/carlielambert/sfslfb1hhg5tz42k/wish/834711545