Law of B&T by Meghan Holloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc en-us 2025-10-14 22:14:05 UTC 2025-10-21 18:29:48 UTC hello@padlet.com https://padlet.net/icons/8.0/svg/1fa7b.svg directly proportional to their reproductive activity meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455866 high rate of reproducibility = more sensitive

low rate of reproducibility = less sensitive

]]> 2025-10-14 22:14:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455866 inversely proportionate to degree of cellular differentiation meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455867 simple cell = more sensitive

complex cell = less sensitive

]]> 2025-10-14 22:14:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455867 directly proportionate to metabolic activity meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455869 higher metabolic rate = more sensitive

lower metabolic rate = less sensitive

]]> 2025-10-14 22:14:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455869 directly proportionate to length of time cells are in reproductive stage (mitotic phase) meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455870 longer time in reproductive phase = more sensitive

shorter time in reproductive phase = less sensitive


*another way of saying inverse to age*

*younger cells more sensitive as they are closer to reproductive phase than mature cells*

]]> 2025-10-14 22:14:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632455870 Reproductive Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632459469 Very High

]]> 2025-10-14 22:20:26 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632459469 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632459531 2025-10-14 22:20:33 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632459531 What is it? meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632466273 Radiosensitivity is a function of the metabolic state of the cell receiving the exposure.

]]> 2025-10-14 22:31:14 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632466273 Highly Radiosensitive meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632473664 2025-10-14 22:42:56 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632473664 Reproductive Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632473995 Low

]]> 2025-10-14 22:43:31 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632473995 Reproductive Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474111 Adult: very low

Fetus: very high

]]> 2025-10-14 22:43:39 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474111 Reproductive Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474203 Spermatogonia: very high

Ova: moderate to high depending on age of person

]]> 2025-10-14 22:43:43 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474203 Cellular Differentiation: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474586 Simple (undifferentiated)

]]> 2025-10-14 22:44:23 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474586 Cellular Differentiation: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474944 Complex (differentiated)

]]> 2025-10-14 22:44:42 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632474944 Lymphocytes meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632475161 MOST RADIOSENSITIVE

Reproductive Activity: None but continuously replenished

Cellular Differentiation: Complex (developed immune cells)

Dose it takes to effect: 0.25 Gy depresses numbers but 0.5 - 1 Gy drops blood count to 0

Recovery time: Slow

*mature but sensitive*

]]> 2025-10-14 22:45:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632475161 Cellular Differentiation: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632476263 Both Adult & Fetal: Complex (highly specialized)

]]> 2025-10-14 22:46:23 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632476263 Cellular Differentiation: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632476342 Spermatogonia: Simple

Ova: Simple

]]> 2025-10-14 22:46:27 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632476342 Granulocytes (Neutrophils) meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478148 2nd Most Sensitive of Blood Cells

Reproductive Activity: Replenished from marrow

Cellular Differentiation: Moderate

Dose it takes to effect: 0.25 Gy first effects seen

Recovery time: roughly 2 months

]]> 2025-10-14 22:49:01 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478148 Metabolic Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478277 High

]]> 2025-10-14 22:49:14 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478277 Metabolic Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478574 Low

]]> 2025-10-14 22:49:48 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478574 Metabolic Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478633 Both Adult and Fetal: Low

]]> 2025-10-14 22:49:54 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478633 Metabolic Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478686 Spermatogonia: High

Ova: Active in early development, low once older

]]> 2025-10-14 22:50:00 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478686 Thrombocytes meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478805 3rd Most Sensitive of Blood Cells

Reproductive Activity: Slow, takes time for stem cells

Cellular Differentiation: Moderate

Dose it takes to effect: 0.5 Gy decreases numbers, 1 to 10 Gy depletes cells

Recovery time: roughly 2 months for repopulation

]]> 2025-10-14 22:50:10 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632478805 Reproduction Length: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632479700 Short

]]> 2025-10-14 22:51:26 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632479700 Reproduction Length: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632479945 Long

]]> 2025-10-14 22:51:33 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632479945 Reproduction Length: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632480009 Adult: Close to none

Fetal: Long (into development)

]]> 2025-10-14 22:51:38 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632480009 Reproduction Length: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632480061 Spermatogonia: Short

Ova: Decrease with age until they don't divide

]]> 2025-10-14 22:51:44 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632480061 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482140 2025-10-14 22:55:12 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482140 Radiosensitivity Varies But All Somewhat Sensitive meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482248 2025-10-14 22:55:25 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482248 Radioresitant meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482309 2025-10-14 22:55:32 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482309 Adult: Radioresistant meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482374 2025-10-14 22:55:38 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482374 Highly Radiosensitive Until Mature (varies through lifetime) meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482426 2025-10-14 22:55:43 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482426 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482640 2025-10-14 22:56:07 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632482640 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632486038 2025-10-14 23:01:37 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632486038 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632486745 2025-10-14 23:02:58 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632486745 Relatively Radiosensitive meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632488429 2025-10-14 23:05:50 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632488429 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632488491 2025-10-14 23:05:57 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632488491 Reproductive Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489003 Moderate to High

]]> 2025-10-14 23:06:46 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489003 Cellular Differentiation: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489053 Simple (undifferentiated)

]]> 2025-10-14 23:06:52 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489053 Metabolic Activity: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489126 High

]]> 2025-10-14 23:07:00 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489126 Reproduction Length: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489377 Short

]]> 2025-10-14 23:07:05 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632489377 Absorbed Dose to See Effect: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632546470 1-2 Gy temporary damage

10 Gy+ necrosis

]]> 2025-10-15 00:03:15 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632546470 Absorbed Dose to See Effect: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632546918 roughly 50 Gy

]]> 2025-10-15 00:03:40 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632546918 Absorbed Dose to See Effect: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632547061 roughly 50+ Gy

]]> 2025-10-15 00:03:45 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632547061 Absorbed Dose & Effect: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632547191 Both Spermatogonia & Ova:

  • roughly 0.1 Gy to reduce sperm count / cause menstrual irregularity

  • 2 Gy causes temporary sterility

  • 5+ Gy causes permanent sterility

]]> 2025-10-15 00:03:52 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632547191 Absorbed Dose to See Effect: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553430 2-10 Gy for erythema

]]> 2025-10-15 00:08:53 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553430 Recovery Time: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553670 Short since cells regenerate quickly

]]> 2025-10-15 00:09:07 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553670 Recovery Time: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553929 if damage is to nucleus --> cell death

]]> 2025-10-15 00:09:20 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632553929 Recovery Time: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632554011 May not recover, signals not delivered if damage is to dendrite or axon


Fetal cells are highly sensitive and can lead to congenital defects

]]> 2025-10-15 00:09:25 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632554011 Recovery Time: meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632554326 1-2 weeks for erythema damage

Slower/permanent damage from higher doses

]]> 2025-10-15 00:09:41 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632554326 Fetal: Radiosensitive meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632577170 2025-10-15 00:24:17 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3632577170 Erythrocytes meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636285363 Least Sensitive of Blood Cells

Reproductive Activity: Mature RBC don't divide but replenished roughly every 120 days

Cellular Differentiation: Complex (highly differentiated)

Dose it takes to effect: 2+ Gy to see effects on marrow

Recovery time: Several months

]]> 2025-10-16 18:07:16 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636285363 Bloody Germs Eat Skin, Muscle, & Nerves meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636553918 Catchy way to remember it!

  • Bloody - Blood cells (Hemopoietic)

  • Germs - Germ cells (Spermatogonia/Ova)

  • Eat - Epithelial cells

  • Skin - skin basilar cells

  • Muscle - muscle cells/tissue

  • Nerves - Nerve tissue (but fetal cells are higher on list)

]]> 2025-10-16 23:41:55 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636553918 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636616714 2025-10-17 00:35:32 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636616714 meghanholloman https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636626129 2025-10-17 00:40:52 UTC https://padlet.com/meghanholloman/rrdcdr2e4ghesvfc/wish/3636626129