by Robyn

Freidrich Miescher

ribboncw2 — 2014-10-21 14:27:27 UTC

Elijah

2014-10-21 19:32:13 UTC

Did his work in 1869 and published it in 1871

2014-10-21 19:35:01 UTC

Identified DNA, and nucleic acid, but did not figure out the function. Paved the way for Molecular discoveries

2014-10-21 19:35:05 UTC

2014-10-21 19:36:06 UTC

Nuclein

ribboncw2 — 2014-10-21 19:40:41 UTC

worked in a hospital, collected pus from bandages, used an alkali solution to examine cells. The salt and alkaline solution caused the cells to burst.

what he termed "nuclein" precipitated out

notice that it was made up of phophorus

- recalled that DNA is made up of sugar phophate backbone

- Meischer was not able to understand the importance of phosphorus while he was alive

- Phoebus Levene from Meischer's work was able to understand that in the nucleus there was a mix of proteins and nucleic acids

- Levene propsoed the tetranucleotide theory - 4 different nucleotides, each with a different chemical structure and linked by a phophodiester bond.

- looked a DNA as a repeating polymer of tetranucleotides

Worked at University of Tubingen in Germany

2014-10-21 19:55:50 UTC