---->@  released at ganglia from presynaptic nerve endings (both systems; end PNS & SNS)
Norepinephrine (NE)-adrenergic

---->@ released at postganglionic nerve endings
Epinephrine (EPI)-adrenergic

---->@ produced by adrenal medulla
Dopamine (DA)
----> Prescursor to NE (Norepinephrine), released @ postganglionic nerve endings

Adrenergic Agonists
This category works by Stimulates all alpha and beta receptors, an exception *AN EXCEPTION BECAUSE IT STIMULATES ALL*

Vasopressor-vasoconstriction, increases BP, Cardiac stimulant, Bronchodilator

Alpha-1 Adrenergic Blocking Drugs

binds to alpha-1 receptors and blocks them

relaxation of smooth muscle, vasodilation of blood vessels, decreases BP, relaxes smooth muscle of ureters and increases urine flow

Beta Adrenergic Agonists
Beta -1 Adrenergic Agonists
Low dose-stimulates dopaminergic (d-1) receptors in kidneys causing vasodilation and increased renal blood flow

Moderate dose-stimulates  beta 1 receptors-heart, increases force of contraction and cardiac output 

High dose- stimulates alpha-1 receptors causing vasoconstriction à increase in blood pressure

Beta Adrenergic Agonists
Beta-2 Adrenergic Agonists 
stimulates beta 2 receptors, relaxation of the smooth muscle of the lungs à bronchodilation, relaxation of the smooth muscle of the uterus

Beta-Adrenergic Blocking Drugs
Selective Beta-1 Blockers
beta-1 receptor is blocked (antagonizes beta-1 effects of NE and EPI)  , decreases force of contraction  (negative inotropic), decreases cardiac output, decreases HR  (negative chronotropic) , decreases conduction (negative dromotropic), decrease in cardiac output also decreases BP

Beta-Adrenergic Blocking Drugs
Non-selective Beta Blockers 
block beta-1 and beta-2 receptors , decreases force of contraction  (negative inotropic), decreases cardiac output, decreases HR  (negative chronotropic) , decreases conduction (negative dromotropic), decrease in cardiac output also decreases BP, can cause bronchoconstriction

1. ephedrine-increases BP

2. phenylephrine (Neo-Synephrine®)- increases BP, nasal decongestant

Adrenergic Agonists
(mimic sympathetic system)
Drugs:

1. epinephrine (Adrenalin®)

Alpha-1 Adrenergic Blocking Drugs
(Block adrenergic or sympathetic system @ the Alpha 1’s) 
Drugs: 

1. prazosin (Minipress®)-HTN

2. terazosin (Hytrin®) -HTN, BPH 

3. doxazosin (Cardura®)-HTN, BPH

Beta-1 Adrenergic Agonists
Drugs:

1. dobutamine

1. albuterol (Proventil®, Ventolin®)-bronchodilator

2. terbutaline (Brethine®)-bronchodilator, uterine relaxant

3. formoterol (Foradil®)-bronchodilator

4. salmeterol (Serevent®)-bronchodilator **LONG ACTING**

Beta-Adrenergic Blocking Drugs- Selective Beta-1 Blockers
Drugs:

  1. atenolol (Tenormin®)

  2. metoprolol (Lopressor®)

      1. nadolol (Corgard®)

      2. propanolol(Inderal®) 

       3. timolol (Blocadren®)