Genomics Case 2 Question 3A by https://padlet.com/haspelr/rd1i6nspy7mm9lpp In looking at the testing report, you note that the first page of the appendix there is a list of “Variants of Unknown Significance.” en-us 2021-09-16 15:09:44 UTC 2021-10-28 12:31:11 UTC hello@padlet.com “Variants of Unknown Significance” haspelr https://padlet.com/haspelr/rd1i6nspy7mm9lpp/wish/1746277674 Using ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/), what is the reported clinical significance of the BRCA2 p.H2074N variant and based on what evidence? 
 
HINTS 
i.  Search ClinVar using “H2074N”
ii. Scroll down to Submitted Interpretations and Evidence. Review any Comments (in the Supporting Information column on the right).
iii.  Scroll down to Citations for this Variant. Review any PubMed links that seem of interest-based on the title. (Note: To identify mention of the variant in a paper or abstract, you can use the find function and search for “2074” or “6220”.)  Specifically, look at the Easton paper.

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