The third largest extinction in Earth's history, the Ordovician-Silurian mass extinction had two peak dying times separated by hundreds of thousands of years. During the Ordovician, most life was in the sea, so it was sea creatures such as trilobites, brachiopods and graptolites that were drastically reduced in number.

Three quarters of all species on Earth died out in the Late Devonian mass extinction, though it may have been a series of extinctions over several million years, rather than a single event. Life in the shallow seas were the worst affected, and reefs took a hammering, not returning to their former glory until new types of coral evolved over 100 million years later.

The Permian mass extinction has been nicknamed The Great Dying, since a staggering 96% of species died out. All life on Earth today is descended from the 4% of species that survived.

During the final 18 million years of the Triassic period, there were two or three phases of extinction whose combined effects created the Triassic-Jurassic mass extinction event. Climate change, flood basalt eruptions and an asteroid impact have all been blamed for this loss of life.