Impact of First-Pass Effect on Drug’s Bioavailability on Oral Administration by https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb 19146053 AARSHI MAHELAKA; 19146054 SUMAYA BINTY HUSSAIN; 19146055 NUZHAT TABASSUM; 19146056 MUMTAHINA SADIA; 19146057 NUSRAT JAHAN; en-us 2021-06-07 17:04:37 UTC 2025-12-30 15:05:48 UTC hello@padlet.com INTRODUCTION mumtahinasadia https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590622181
  • The amount of blood perfusing the liver that is cleared of the medication per unit of time is known as hepatic drug clearance. 
  • Many medications are metabolized in the liver, sometimes to the point that only a little quantity of active substance makes it to the remainder of the circulatory system. 
  • Results of this first trip through the liver, the drug's bioavailability may be considerably reduced.




    • ]]>     2021-06-07 17:19:27 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590622181     Oral Bioavailability on First Pass Effect mumtahinasadia https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590634840
  • Methodologist experimental for assessing factors affecting oral bioavailability in vivo
  • Individual contributions due to absorption and gut lumen losses appear to be estimated using an integrated set of approaches. 
  • Assumed treatment of linear pK and constant clearance
  • This determine metabolite bioavailability

    • ]]>     2021-06-07 17:23:55 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590634840     Bioavailability for drugs with a high first-pass effect using oral clearance mumtahinasadia https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590647642
  • A straight line with an intercept of unity and a slope of reciprocal of hepatic blood flow results from charting the reciprocal of bioavailability vs Oral clearance
  •  Lignocaine and verapamil : shows strong and good predictability Propranolol: shows poor predictability
  •   Useful in terms of detection of a drug's limited bioavailability



    • ]]>     2021-06-07 17:28:35 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590647642     CONCLUSION mumtahinasadia https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590650375  
    • Oral dose of drugs having higher first pass impact than others
    • There is significant individual variation in the oral dose
    •  For this bioavailability raised in patients with impaired liver function
    • It keeps serum drug concentrations stay within patient’s therapeutic ranges
    • This maximises patients safety and therapy efficacy
    ]]>     2021-06-07 17:29:36 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1590650375     mumtahinasadia https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1591150916 2021-06-07 21:34:13 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1591150916 Main Focus: https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592087485
  • Drug taken orally, pass via liver before going systemic circulation, removed by metabolism or hepatobiliary secretion.
  • Factors - plasma protein concentration, enzymatic activity, gastriontestinal motility.
  • The drugs bioavailability may be considerably reduced.
  • First pass metabolism-
    • Swallowed drug→Digestive system→Hepatic portal system→Liver→Rest of the body

    ]]>     2021-06-08 06:21:10 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592087485     medha6683 https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592347349 2021-06-08 08:40:57 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592347349 medha6683 https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592355995 2021-06-08 08:46:03 UTC https://padlet.com/mumtahinasadia/r7ktw14tj3lsvalb/wish/1592355995