Neurofibromatosis Type 1 (NF1) by Alejandro Ceva https://padlet.com/aceva221/qnr3b18culbkdps6 Signal Transduction Pathway en-us 2020-12-18 17:09:54 UTC 2024-11-20 19:49:03 UTC hello@padlet.com Disease Basics aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031937213
  • Genetic disorder which disrupts the production of Neurofibromin proteins
  • Results in tumors growing along your nerve cells
  • Symptoms include hearing loss, learning impairment, cardiovascular problems, loss of vision, severe pain
    • ]]>     2020-12-18 17:12:12 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031937213     Function of Neurofibromin Protein aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031958351 Tumor Suppressor -
    • Related to Guanosine Triphosphate Activating Protein (GAP)
    • Acts as an on and off switch for RAS which is responsible for growth and proliferation

    Boosts learning/memory -
    • Modulates Adenylyl cyclase which catalyzes the reaction from ATP to cAMP (a secondary messenger which which activates PKA leading to learning and memory)
    • Binds with microtubules
    ]]>     2020-12-18 17:17:09 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031958351     aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031976614 BASICS]]> 2020-12-18 17:21:49 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031976614 SIGNAL TRANSDUCTION PATHWAY aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031988134 2020-12-18 17:24:41 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031988134 Receptor Tyrosine Kinase aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031992149
  • KIT Ligand binds causing dimerization
  • Activates the kinase activity and leads to autophosphorylation 
  • Proteins attach to the sites causing a change in shape and a signal to be produced
    • ]]>     2020-12-18 17:25:42 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1031992149     Correct Pathway aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032025443 MAPK Pathway (RAS/mitogen-activated protein kinase) - 
    • Neurofibromin (when functioning properly) helps to inhibit p21 RAS activity
      • Converts the active GTP-bound form to the inactive GDP-bound form
    • Modulates Adenylyl cyclase and binds to microtubules

    ]]>     2020-12-18 17:34:12 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032025443     Incorrect Pathway aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032051257 MAPK Pathway (RAS/mitogen-activated protein kinase) - Because of NF1, Neurofibromin is not active in transduction
    • RAS becomes hyperactive which leads to increased growth and proliferation resulting in tumors
    • Adenylyl Cyclase no longer as effective, microtubules are not bound to - memory/learning impaired

    ]]>     2020-12-18 17:40:22 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032051257     aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032054950 2020-12-18 17:41:19 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032054950 aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032057134 2020-12-18 17:41:50 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032057134 aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032058630 2020-12-18 17:42:13 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032058630 TREATMENT AND RESEARCH aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032075122 2020-12-18 17:46:13 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032075122 Treatment aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032078644
  • Surgery can be considered for some tumors
  • Radiation and Chemotherapy are also used to treat some NF1 tumors
  • MEK Inhibitor
    • Most promising treatment right now
    • ]]>     2020-12-18 17:47:10 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032078644     Research aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032085184
  • Using viruses to kill tumor cells
  • Additional testing of radiation and chemotherapy regiments for NF1 tumors on nerve cells
  • Further research into kinase protein inhibitors
    • ]]>     2020-12-18 17:48:53 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032085184     CONNECTIONS TO OTHER TOPICS: aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032093399 2020-12-18 17:50:37 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032093399 aceva221 https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032096531 1. Cell Membrane
    • Proteins embedded inside
    2. Enzymes
    • GAPase, adenylyl cyclase
    4. Amino Acids
    • Sequence of animo acids determine protein function
    5. Cellular Respiration
    • ATP production fuels many of the reactions
    6. DNA
    • Has the recipe for proteins
    • Gene mutation is what causes disease
    ]]>     2020-12-18 17:51:28 UTC https://padlet.com/aceva221/qnr3b18culbkdps6/wish/1032096531