Hemophilia by Isabel Davis https://padlet.com/isabeldavis19/qnddb4qky745 Pathological Disease Project: Blood en-us 2018-02-07 22:05:16 UTC 2018-02-12 22:01:43 UTC hello@padlet.com Citations isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229842160 Hemophilia. (2017). In CareNotes and Truven Health Analytics. Retrieved from http://link.galegroup.com/apps/doc/A503762464/HWRC?u=mtlib_2_754&sid=HWRC&xid=c1a4db30
Hemophilia C. (2017, December 06) from Medscape. Retrieved from https://emedicine.medscape.com/article/955690-overview
Wilson, J. F., & Lee, C. L. (2015). Hemophilia. In J. L. Longe (Ed.), The Gale Encyclopedia of Medicine (5th ed.). Farmington Hills, MI: Gale. Retrieved from http://link.galegroup.com/apps/doc/TTYKDU693945168/HWRC?u=mtlib_2_754&sid=HWRC&xid=9822c976
Hemophilia. (2017, March 02). Retrieved February 12, 2018, from https://www.cdc.gov/ncbddd/hemophilia/facts.html
 ]]> 2018-02-08 21:58:50 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229842160 What is Hemophilia? isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229842324 Hemophilia is a coagulation disorder of the blood that results in a lack of platelets, clotting factors, vitamin K, and fibrinogen in individuals. These affect the blood's ability to form a clot, meaning that individuals with hemophilia bleed more and longer than normal due to certain clotting factors that are either decreased in quantity, absent, or improperly formed. It can be mild, moderate, or severe based on the kind of bleeding episode, form of injury, or amount of present clotting factors. These episodes can be a result of injuries or simple actions, and the bleeding can be internal.]]> 2018-02-08 21:59:27 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229842324 Hemophilia A (Classic Hemophilia) isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229843843 Type A means that the level of the clotting factor IX (nine) is lower than normal]]> 2018-02-08 22:05:42 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229843843 Hemophilia B (Christmas Disease) isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229844281 Type B means that the level of the clotting factor VII (eight) is lower than normal]]> 2018-02-08 22:07:49 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229844281 Symptoms and Severity isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229845282 Both Hemophilia A and B have similar symptoms and can levels of severity of bleeding episodes can vary.]]> 2018-02-08 22:11:47 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229845282 How can you treat this disease? isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846118 There is no current cure for Hemophilia, but there are treatments that depend on the type and severity of symptoms.
The most important thing that individuals with hemophilia can do to prevent complications of this disease is to avoid injury. 
Replacement therapy to replace the clotting factor that is missing or present in low amounts is the most common method of treatment. People with hemophilia are also typically vaccinated against hepatitis.
Desmopressin is a medicine that will help increase the amount of clotting factors in blood.]]> 2018-02-08 22:15:32 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846118 Mild isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846379 Clotting factors are still present and excessive bleeding will probably only occur during surgery or due to a serious injury.]]> 2018-02-08 22:16:54 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846379 Moderate isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846400 The clotting factors are low and episodes may occur suddenly from small injuries. Excessive bleeding will likely occur during surgery.]]> 2018-02-08 22:16:58 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846400 Severe isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846428 There are very low levels of clotting factors and sudden bleeding can come from muslces, joints, and more]]> 2018-02-08 22:17:04 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846428 What does a hemophiliac experience? isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846996 Frequent bleeding from your gums or nose
Heavy bleeding from injuries or after surgeries or dental work
Painful bruises that form easily after you bump a body area
Bowel movements that are black
Urine that is pink or red
Stiff, painful, or swollen joints
]]> 2018-02-08 22:19:19 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229846996 How is Hemophilia transferred? isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229849044 Hemophilia A and B are both caused by a genetic defect present on the X chromosome. About 70% of all people with hemophilia A or B inherited the disease, and the other 30% develop it through a spontaneous gene mutation. Since the trait is carried only on the X chromosome, it is a sex-linked genetic defect. Hemophilia A and B are observed in all ethnic and racial groups, with some prevalence reported in Chinese populations.]]> 2018-02-08 22:28:19 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229849044 Hemophilia C isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/229849845 This type is a milder form and is a factor XI deficiency, meaning both sexes are affected]]> 2018-02-08 22:32:06 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/229849845 isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230801570 A blow to the head, which might be totally insignificant in a normal individual, can result in bleeding into the skull and brain. Because the skull has no room for expansion, a person with hemophilia is at risk for brain damage due to blood taking up space and exerting pressure on the delicate brain tissue.]]> 2018-02-12 19:54:07 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/230801570 isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230803418 Recently, concern has been raised about the possibility of hemophiliacs contracting Creutzfeldt–Jakob Disease from blood products. 
Also, many pooled factor preparations in the 1980s were contaminated with human immunodeficiency virus (HIV). Many hemophiliacs were infected with HIV and some statistics show that HIV is still the leading cause of death among hemophiliacs. Careful methods of donor testing, as well as methods of inactivating viruses present in donated blood, have greatly lowered this risk.]]> 2018-02-12 19:57:07 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/230803418 isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230806244 Wilson, J. F., & Lee, C. L. (2015). Hemophilia. In J. L. Longe (Ed.), The Gale Encyclopedia of Medicine (5th ed.)]]> 2018-02-12 20:02:40 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/230806244 isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230815521 “Hemophilia: A Genetic Disorder.” Google Sites, sites.google.com/a/brvgs.k12.va.us/hemophilia-a-genetic-disorder/]]> 2018-02-12 20:21:20 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/230815521 isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230816683 A baby suffering from hemophilia, showing a large area of bruising (hemorrhaging) over the infants... (2016). In D. S. Blanchfield (Ed.), The Gale Encyclopedia of Children's Health: Infancy through Adolescence (3rd ed., Vol. 1). Farmington Hills, MI: Gale. Retrieved from http://link.galegroup.com/apps/doc/PC3630987044/HWRC?u=mtlib_2_754&sid=HWRC&xid=9d2f2dc0

An internal hemorrhage occurring on a baby suffering from hemophilia.]]> 2018-02-12 20:23:56 UTC https://padlet.com/isabeldavis19/qnddb4qky745/wish/230816683 Facts isabeldavis19 https://padlet.com/isabeldavis19/qnddb4qky745/wish/230823670 The severity of hemophilia that a person has is determined by the amount of factor in the blood. The lower the amount of the factor, the more likely it is that bleeding will occur.

The X chromosome contains many genes that are not present on the Y chromosome. This means that males only have one copy of most of the genes on the X chromosome, whereas females have 2 copies. Because of this, males can have a disease like hemophilia if they inherit an affected X chromosome whereas it is much rarer for females to have an X chromosome related disease.

Hemophilia occurs in about 1 of every 5,000 male births. Currently, about 20,000 males in the United States are living with the disorder.

Hemophilia A and B are observed in all ethnic and racial groups, with some prevalence reported in Chinese populations.


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