2. Brand Name: Dopastat, Introstat, Revimine

 3. Stock Dosage: 

·         Injection - 40 mg/mL, 80 mg/mL, 160 mg/mL injection

4. Classification: Autonomic Nervous System Agent, Alpha- and Beta-Adrenergic Agonist (Sympathomimetic)

5. Mechanism of Action: Naturally occurring neurotransmitter and immediate precursor of norepinephrine. Major cardiovascular effects produced by direct action on alpha- and beta-adrenergic receptors and on specific dopaminergic receptors in mesenteric and renal vascular beds.

6. Indication/s:

·         Correction of hemodynamic balance in shock syndrome due to myocardial infarction

·         Trauma

·         Endotoxic Septicemia (septic shock) 

·         Open Heart Surgery

·         Chronic Heart Failure 

 7. Contraindications

·         Pheochromocytoma

·         Tachyarrhythmias 

·         Ventricular Fibrillation

 8. Side Effects and Adverse Effects

·         CV: Hypotension, ectopic beats, tachycardia, anginal pain, palpitation, vasoconstriction, cold extremities, bradycardia, , elevated blood pressure. 

·         GI: Nausea, vomiting.

·         CNS: Headache. 

·         Skin: Necrosis, tissue sloughing with extravasation, gangrene.

·         Other: Azotemia, dyspnea, dilated pupils (high doses).

 9. Nursing Responsibilities

·         Monitor blood pressure, pulse, peripheral pulses, and urinary output. 

·         Monitor therapeutic effectiveness.

·         Report the following indicators promptly to physician: Reduced urine flow rate in absence of hypotension; ascending tachycardia; dysrhythmias; disproportionate rise in diastolic pressure (marked decrease in pulse pressure); signs of peripheral ischemia (pallor, cyanosis, mottling, coldness, complaints of tenderness, pain, numbness, or burning sensation).

 

·         Tablets: 10 mg, 20 mg, 40 mg

 4. Classification: Cardiovascular Agent, Antilipemic Agnet, HMG-COA; Reductase Inhibitor (Statin)

5. Mechanism of Action: Atorvastatin is an inhibitor of reductase 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA), which is essential to hepatic production of cholesterol. Lipitor increases the number of hepatic low-density-lipid (LDL) receptors, thus increasing LDL uptake and catabolism of LDL.

·         Adjunct to diet for the reduction of LDL cholesterol and triglycerides in patients with primary hypercholesterolemia and mixed dyslipidemia.
 

·         Hypersensitivity to atorvastatin

·         Myopathy

·         Active Liver Disease

·         Unexplained Persistent Transaminase Elevations 

·         Pregnancy (category X)

·         Lactation
 

·         Body as a Whole: Back pain, asthenia, hypersensitivity reaction, myalgia, rhabdomyolysis 

·         CNS: Headache

·         GI: Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, increased liver function tests 

·         Respiratory: Sinusitis, pharyngitis

·         Skin: Rash