HBD3003 Session 4 PM session by Miro Vukic https://padlet.com/mirovukic/pw058pvscb5la0fr Wounds and Wound healing en-us 2020-08-03 05:43:36 UTC 2025-07-23 21:44:21 UTC hello@padlet.com Vascular system mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667786414 2020-08-03 05:45:11 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667786414 Lymphatic System and cells mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667786476 2020-08-03 05:45:20 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667786476 Integumentary system and cells mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787007 2020-08-03 05:46:27 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787007 Endocrine system mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787182 2020-08-03 05:46:46 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787182 Neurological system mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787276 2020-08-03 05:46:58 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787276 Communication and signalling loops mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787386 arachadonic acid, complement and coagulation cascades?]]> 2020-08-03 05:47:13 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667787386 Poor wound healing may be associated with inflammation, angiogenesis, matrix deposition and cell recruitment. https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667808393
this can lead to other chronic conditions within the body such as 
- vascular disease 
- diabetes ]]> 2020-08-03 06:35:22 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667808393 Chronic disease conditions affects millions of people worldwide each year. Contributing factors such as poor regulations of healthy tissue response, including factors such as inflammation, angiogenesis, matrix deposition and cell recruitment. Failure of any of these cellular processes are generally linked to an underlying clinical condition such as vascular disease, diabetes or aging. All of these factors are associated to poor healing. Other chronic conditions are venous leg ulcers, https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809298 2020-08-03 06:37:05 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809298 Wound healing Phases: https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809466 1. inflammatory phases
"Inflammatory cells, such as neutrophils, monocytes, and endothelial cells, adhere to a fibrin scaffold that is formed by platelet activation. The neutrophils enable phagocytosis of cellular debris and bacteria, allowing for decontamination of the wound" (Wallace, 2020)
2. Proliferation phase- formation of granulating tissue, re epithelation and vascular - can take up to 7 weeks and is discrete goes un noticed /  happening in the background. 
3. Maturation Phase 
or re modelling phase.
 ]]> 2020-08-03 06:37:28 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809466 Able to follow the natural stages of the wound healing process, without any interference. https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809546 Prolonged inflammation phase turns into chronic condition]]> 2020-08-03 06:37:40 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667809546 two different outcomes https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667811657 1. Chronic wound 
2. hypertrophic scar/wound]]> 2020-08-03 06:42:53 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667811657 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812169 2020-08-03 06:44:02 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812169 Hyperpigmentation https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812272 Frequently, hyperpigmentation as a consequence of melanocyte recruitment can occur at the wound site, and persist even after a chronic wound has successfully healed.]]> 2020-08-03 06:44:16 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812272 AKA barrier defects https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812462 2020-08-03 06:44:37 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667812462 a majority occur on the lower part of the body' https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667813020 2020-08-03 06:45:39 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667813020 Molecular and cellular mechanisms in normal skin repair https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667813187 2020-08-03 06:46:03 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667813187 Presentation https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815559 Chronic wounds show hyperproliferative and nonmigratory epidermis, unresolved inflammation, presence of infection, and biofilm formation.]]> 2020-08-03 06:50:43 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815559 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815616 Demographically, the number of patients suffering from chronic wounds and impaired healing conditions is reaching epidemic proportions and will become even more burdensome in both human health and economic terms.]]> 2020-08-03 06:50:54 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815616 Chronic wounds definition https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815988 2020-08-03 06:51:48 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667815988 Sodium potassium pump mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667816441 2020-08-03 06:53:17 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667816441 The current of injury https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817521 is a negative feedback loop mechanism for repair and regeneration of the skin. ]]> 2020-08-03 06:56:18 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817521 microbes need to be brought down to a stable level to be cleared and accepted by healthy tissue. https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817597 2020-08-03 06:56:28 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817597 mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817820 2020-08-03 06:56:59 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667817820 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667818711 Chronic, persistent inflammatory response 

A large influx and retention of innate immune cells to chronic wounds is likely to inhibit many repair processes. 

Bactericidal and phagocytic activities may be reduced. 

Build-up of necrotic debris at the wound edge 
]]> 2020-08-03 06:59:06 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667818711 Molecular mechanisms https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819222 Chronic wound edge keratinocytes express a gene signature reflecting partial proliferative activation

Reduced growth factor signalling

Reduced levels of TGF-B receptors ]]> 2020-08-03 07:00:15 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819222 inflammatory response https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819434 2020-08-03 07:00:52 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819434 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819447 2020-08-03 07:00:54 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819447 Cellular Mechanism https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819522 Immune cells migrate to the wound site to orchestrate the healing process 

Upregulation of wound-associated genes enabling collective cell migration

Local and blood-born fibroblast proliferate and migrate to form the wound granulation tissue 

Deposit new extracellular matrix (ECM) 

Keratinocytes around the wound edge change adhesions so that they can migrate to different parts of the wound- can detach from basement membrane. 

Normal inflammatory response 
]]> 2020-08-03 07:01:06 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819522 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819563 keloids extend beyond the margins of the original tissue damage, do not tend to regress spontaneously, and show a genetic predisposition.]]> 2020-08-03 07:01:13 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667819563 https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667820081 Involves a complex interplay between many cellular mechanisms in the skin, primarily keratinocytes, fibroblast, endothelial cells of vessels and recruited immune cells]]> 2020-08-03 07:02:26 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667820081 surgical usually https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667828557 complete/durable closure


]]> 2020-08-03 07:22:16 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667828557 different stages https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667829934 primary, secondary, tertiary of delayed primary closure 


]]> 2020-08-03 07:25:57 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667829934 Tissue Repair https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667830862 Healing occurs via regeneration or replacement. regeneration is that the tissue is the same as before injury - repaired to the same state. ]]> 2020-08-03 07:28:18 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667830862 📹Tertiary Intention https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667831541 2020-08-03 07:30:07 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667831541 Hypertrophic vs. keloid https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667836256 2020-08-03 07:41:58 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667836256 Hypertrophic vs. keloid https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667836310 2020-08-03 07:42:06 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667836310 Acute Wounds mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861221 2020-08-03 08:53:44 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861221 Chronic Wounds/Ulcers/different categories? mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861271 2020-08-03 08:53:52 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861271 Burns mirovukic https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861361 What grading systems are used?]]> 2020-08-03 08:54:08 UTC https://padlet.com/mirovukic/pw058pvscb5la0fr/wish/667861361