Drug Study - Torres, Alyson Getsie M. by Alyson Getsie Torres https://padlet.com/torresalysongetsie/puxtduoea62cih23 Clopidogrel & Digoxin en-us 2021-09-17 06:58:21 UTC 2024-05-28 17:23:01 UTC hello@padlet.com Clopidogrel torresalysongetsie https://padlet.com/torresalysongetsie/puxtduoea62cih23/wish/1748039377
  • Generic Name: clopidogrel

    • Brand Name: Apo-Clopidogrel

    • Stock Dosage:
    Tablets: 75 mg, 300 mg; PO (avoid grapefruit products)

    • Classification:
    • Pharmacotherapeutic: Thienopyridine derivative
    • Clinical: Antiplatelet

    • Mechanism of Action:
    This drug inhibits the binding of enzyme adenosine phosphate (ADP) to its platelet receptor and subsequent ADP-mediated activation of glycoprotein complex with a a therapeutic effect: inhibits platelet aggregation


    • Indication/s:
    To decrease rate of Myocardial Infarction and stroke in patients with non-ST segment elevation acute coronary syndrome (ACS), acute ST-elevation MI(STEMI), patients with history of recent Myocardial Infarction or stroke, established peripheral arterial disease (PAD) 

    - Recent MI, Stroke, PAD
    PO: Adults, Elderly = 75 mg once a day

    - Unstable Angina/NSTEMI
    PO: Adults, Elderly(<75 y/o) = loading dose 300-600 mg, then 75 mg once a day in combination with aspirin for up to 12 months while indefinitely for aspirin)


    • Contraindications:
    Contraindicated to patients with hypersensitivity to clopidogrel and active bleeding


    • Side Effects and Adverse Effects:
    - Frequent side effects (15%): Skin disorders
    - Occasional side effects (8-6%): UTI, chest pain, flu-like symptoms, headache, dizziness, arthralgia
    - Rare Effects (5-3%): Fatigue, edema, hypertension

    • Nursing Responsibilities
    - Conduct baseline assessment: platelet count
    - Monitor platelet count for evidence of thrombocytopenia
    - Assess Hgb, Hct
    - Report any unusual bleeding


    Source: 

    Hodgson, B., & Kizior, R. (2019). Saunders Nursing Drug Handbook 2019. St. Louis: Elsevier.

    ]]>     2021-09-17 07:03:28 UTC https://padlet.com/torresalysongetsie/puxtduoea62cih23/wish/1748039377     Digoxin torresalysongetsie https://padlet.com/torresalysongetsie/puxtduoea62cih23/wish/1748041933
  • Generic Name: digoxin

    • Brand Name: Lanoxin

    • Stock Dosage: 
    - Oral Solution (Lanoxin): 50 mcg/mL
    - Injection Solution (Lanoxin): 100 mcg/mL, 250 mcg/mL
    - Tablets (Lanoxin): 62.5 mcg, 125 mcg, 187.5 mcg, 250 mcg

    • Classification:
    - Pharmacotherapeutic: Cardiac glycoside
    - Clinical: Antiarrhythmic, cardiotonic

    • Mechanism of Action:
    Heart failure: Inhibits sodium/potassium ATPase pump in myocardial cells. Promotes calcium influx
    Supraventricular Arrhythmias: Suppresses AV node conduction

    • Indication/s:
    Treatment of mild to moderate heart failure. Control ventricular response rate in patients with chronic atrial fibrillation 

    • Contraindications:
    Contraindicated to patients with hypersensitivity to digoxin 

    • Side Effects and Adverse Effects:
    Dizziness, headache, diarrhea, rash, visual disturbances

    • Nursing Responsibilities:
    - Assess apical pulse, if it is 60 or less/min withhold drug and contact physician
    - Monitor pulse for bradycardia, EKG for arrhythmias for 1-2 hours after administration 
    - Do not increase or skip doses

    Source: 

    Hodgson, B., & Kizior, R. (2019). Saunders Nursing Drug Handbook 2019. St. Louis: Elsevier.



    ]]>     2021-09-17 07:05:10 UTC https://padlet.com/torresalysongetsie/puxtduoea62cih23/wish/1748041933