Bone's functional adaptation to loading by Galea, Gabriel https://padlet.com/ggalea1/phv3k58dfdhjouk9 Add steps below, or reposition pre-placed steps by clicking and dragging them along the timeline. You are aiming to describe the sequence of events involved in functional adaptation. The start and end are highlighted green - keep these where they are. en-us 2020-07-27 17:16:02 UTC 2021-10-14 07:35:46 UTC hello@padlet.com Canonical Wnt signalling increases ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663458570 The transcription factor B-Catenin translocates to the nucleus where it promotes expression of target genes involved in osteoblast proliferation and differentiation]]> 2020-07-27 17:17:44 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663458570 Loading deforms the bone matrix ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663459294 This produces mechanical strain and fluid flow]]> 2020-07-27 17:18:57 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663459294 Mechanical loading event ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663461424 Bone is subjected to a level of loading which exceeds what is habituated to]]> 2020-07-27 17:22:18 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/663461424 Osteocyte dendrites and cell membranes are deformed. ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682534299 This triggers mechanically-activated signalling such as opening stretch-activated Ca channels and pulling on integrins]]> 2020-08-17 12:01:44 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682534299 Inactive lining osteoblasts become active ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682536126 Osteoblast number may also increase through differentiation of pre-osteoblasts or proliferation.]]> 2020-08-17 12:04:17 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682536126 Bone is now stronger ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682537668 Bone mass is now greater and its architecture has adapted to the new loads. ]]> 2020-08-17 12:06:20 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682537668 Functional adaptation is complete ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682538606 Mechanical strain levels have returned to the safe 'target' at the new level of loading]]> 2020-08-17 12:07:27 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/682538606 Got questions for me? Please ask here and I will do my best to reply! Gabriel ggalea1 https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/686859122 Q1)
Q2)]]> 2020-08-19 12:20:34 UTC https://padlet.com/ggalea1/phv3k58dfdhjouk9/wish/686859122