https://padlet.com/lovrencic_m43/aspirin KEMIJA en-us 2020-02-10 19:24:05 UTC 2023-05-20 15:56:15 UTC hello@padlet.com https://padlet.net/icons/png/1f9ea.png lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443280117 2020-02-10 19:27:48 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443280117 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443280593 Grupa : 
Antiupalni lijekovi
Antipiretici
Analgetici]]> 2020-02-10 19:28:26 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443280593 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443282044  C₉H₈O₄]]> 2020-02-10 19:30:21 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443282044 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443283481 Trgovačka imena 
Andol®            Acesal®           Alka- Seltzer®]]> 2020-02-10 19:32:18 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443283481 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443288099 2020-02-10 19:38:19 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443288099 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443288450 2020-02-10 19:38:43 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443288450 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443288804 2020-02-10 19:39:10 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443288804 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443292294 2020-02-10 19:43:33 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443292294 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443295292 - reakcija esterifikacije
-salicilnoj kiselini (kao reaktantu )se dodaje acetatni anhidrat   (derivat acetatne kiseline)
-uz prisustvo katalizatora 85%-ne fosfatne kiseline (H₃PO₄)    - (ponekad  i sumporne kiseline H₂SO₄)
-nastaje acetilsalicilna kiselina i kao nusprodukt, acetatnu kiselinu ( CH3COOH )
-acetatni anhidrat se veže na fenolnu grupu salicilne kiseline (OH-) -pretvarajući je u acetil-grupu (R-OH → R-OCOCH₃)

]]> 2020-02-10 19:47:33 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443295292 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/443310638 - aspirin se može razložiti putem hidrolize u vlažnim uvjetima na salicilnu i acetatnu kiselinu.

-Konstanta kisele disocijacije (pKa) za acetilsalicilnu kiselinu iznosi 3,5 na temperaturi od 25 °C

- Alternativno:
može se sintetizirati reakcijom salicilne kiseline i acetil klorida
čime se pored acetilsalicilne kiseline kao nusproizvod dobija HCl (klorovodična kiselina)]]> 2020-02-10 20:07:37 UTC https://padlet.com/lovrencic_m43/aspirin/wish/443310638 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447095760 -alkohol+ kiselina +ester
-aspirin je lijek koji ublažava bol i smanjuje vrućicu
-sadrži derivate salicilne kiseline
-njemački kemičar Felix Hoffman koristio ga kao tretman za očev artritis

]]> 2020-02-18 20:51:14 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447095760 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447099174 - Hipokrat navodi da kora i lišće vrbe ublažavaju bol i vrućicu
- popularnost lijeka je pala nakon otpuštanja paracetamola (1956.) ibuprofena u (1969.)



]]> 2020-02-18 20:58:22 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447099174 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447101015 - koristi se za ublažavanje mnogih vrsta bolova i bolova glavobolje
-zubobolja
-bol u mišićima
-menstrualni grčevi
-bolovi u zglobovima (artritis)
-smanjuje srčani i moždani  udar
-prevencija replikacije HIV-a]]> 2020-02-18 21:03:16 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447101015 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447103103 -za liječenje boli i artritisa
-kod psa, konja itd.
- životinje također moraju biti pod nadzorom]]> 2020-02-18 21:08:24 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447103103 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447105470 - djecu mlađu od 16 god
-astmatičare
-žene u posljednjem tromjesečju trudnoće
-osobe koje konzumiraju alkohol u velikim količinama
-osobe s poremećajima krvarenja]]> 2020-02-18 21:13:39 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447105470 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447107082 -talište 135°C
-vrelište 140°C
-topljivost 0.3 g u 100 mL H₂O (20 °C)
-bez mirisa
-bezbojan
-gustoća 1.35 g cm ^-3
-molarna masa: 180.16 g mol ^-1

]]> 2020-02-18 21:17:30 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447107082 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447110024 -nadražen želudac
-gubitak apetita 
-vrućica
-žeđ
-oštećenje jetre
-kihanje i zamućenje u oku]]> 2020-02-18 21:25:06 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447110024 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447110340 -biljka proizvodi salicilnu kiselinu
-dodavanje otopljenog apsirina biljkama može uzrokovati isti efekt kao infekciju-namjerno pokreće da se ojača

]]> 2020-02-18 21:25:58 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447110340 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447113698 - proces:

- vaganje 
-miješanje - stroj- Glen Mikser
-propuštanje kroz mrežastu podlogu-ručnom lopaticom od nehrđajućeg čelika
-kompresija
- testiranje
-punjenje i pakiranje-tablete se prenose na montažnu liniju za punjenje
-ispuštene u prozirne ili obojene polietilenske boce ili staklene
-zapečaćen u aluminiju
-oznake i informacije o proizvodu, datum isteka
-pakiranje u kartonske kutijice

]]> 2020-02-18 21:34:31 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447113698 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447116726 -kukuruzni škrob i voda dodaju se acetilsalicilatnoj kiselini kako bi služili kao sredstvo za vezanje
-lubrikant se dodaje tijekom miješanja (hidrogenirano biljno ulje, stearinska kiselina)
-aspirin tablete sadrže različite razrjeđivače, kao što su manitol, laktoza, sorbitol, saharoza koji omogućuju da se tableta otopi brže i daju lijeku ugodan okus

]]> 2020-02-18 21:42:19 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447116726 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447120687 -tablete proizvedene u različitim oblicima  (težina, veličina, debljina i tvrdoća)
-tablete mogu biti ravne, okrugle, konkavne ili konveksne na različite
-tablete također mogu imati liniju s razdjelnom crtom na sredini vanjske površine]]> 2020-02-18 21:52:16 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447120687 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447128666 2020-02-18 22:18:54 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447128666 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447134820 2020-02-18 22:41:04 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447134820 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447135690 2020-02-18 22:44:00 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447135690 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447136241 2020-02-18 22:45:56 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447136241 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447136562 2020-02-18 22:47:03 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447136562 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447137698 brzo se raspada u otopinama amonijevog acetata ili acetata, karbonata, citrata ili hidroksida alikalijskih metala]]> 2020-02-18 22:50:33 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447137698 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447138897 2020-02-18 22:54:18 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447138897 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447139625 -može se napraviti pasta pomoću mljevenog aspirina i vode koja se stavlja na mrlju prije pranja

salicilna kiselina u aspirinu je učinkovito sredstvo za čišćenje]]> 2020-02-18 22:56:39 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447139625 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447140599 2020-02-18 23:00:11 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447140599 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447140913 -utrljati vlažnu tabletu na mjesto ugriza komaraca]]> 2020-02-18 23:01:26 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447140913 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447141630 -dodati jedan aspirin po galonu vode - cvijeće je dugotrajnije ]]> 2020-02-18 23:03:57 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447141630 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447143171 -za ukljanjanje prhuti iz vlasišta
-smrviti 2 tablete i dodati šampon]]> 2020-02-18 23:09:31 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447143171 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447143452 -dvije tablete smrviti i staviti na hrđu te ostaviti 10 minuta i oprati spužvom]]> 2020-02-18 23:10:27 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447143452 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447146336 2020-02-18 23:20:19 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447146336 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447147173 2020-02-18 23:23:13 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447147173 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447147436 2020-02-18 23:24:11 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447147436 lovrencic_m43 https://padlet.com/lovrencic_m43/aspirin/wish/447147760 2020-02-18 23:25:16 UTC https://padlet.com/lovrencic_m43/aspirin/wish/447147760