Group work_ ECM: mini cases by Gaukhar Yeszhanova https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt Сделано без сожалений. Вообще. en-us 2022-04-21 02:09:30 UTC 2026-03-12 15:14:19 UTC hello@padlet.com Group I yeszhanovagaukhar https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001339 2022-04-22 02:56:27 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001339 Some have speculated that Abraham Lincoln had Marfan’s syndrome, mainly due to his height (6’4” when the average was 5’6”) and his thin physique. What protein is mutated in patients who suffer from Marfan’s syndrome? yeszhanovagaukhar https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001394 2022-04-22 02:56:31 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001394 group II yeszhanovagaukhar https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001794 2022-04-22 02:56:56 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153001794 The glycosaminoglycan polysaccharide chains that are linked to specific core proteins to form the proteoglycan components of the extracellular matrix are highly negatively charged. How do you suppose these negatively charged polysaccharide chains help to establish a hydrated gel-like environment around the cell? How would the properties of these molecules differ if the polysaccharide chains were uncharged? yeszhanovagaukhar https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153002162 2022-04-22 02:57:18 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153002162 https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153246980 Marfan's syndrome is as a result of defects withinside the glycoprotein fibrillin, the majori factor of microfibrils, which binds to elastin and is crucial for the integrity of elastic bers. Patients with mutations withinside the fibrillin gene are frequently tall and lanky int appearance.]]> 2022-04-22 07:30:18 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153246980 https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153249145 Marfan syndrome is a genetic disorder that affects connective tissue. There are many types of connective tissue. It provides strength, elasticity, and cushioning to structures throughout the body. The most common effects of Marfan syndrome are in the areas of the body with the greatest amount of connective tissue. These include the heart, blood vessels, eyes, lungs, and skeleton.

Some people are born with clear features of Marfan syndrome, while others develop symptoms as teens or adults. Marfan syndrome isn't simple to diagnose, and nearly half the affected people never realize they have it.
 Marfan syndrome gets worse with age. Recognizing the symptoms early helps to avoid serious complications later on.]]> 2022-04-22 07:32:32 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153249145 Due to high density of negative charges on polysaccharide components of proteoglycans cause to extend It is to trap an equal number of cations to maintain electrical neutrality. Concentration of particles in the volume of proteoglycan is higher than surrounding and hence the water flows try to equalize the concentration inside and outside.Proteoglycans thus trap water to form a hydrated gel by drawing in water molecules. In absence of negative charge sugar chains will collapse in fibers and granules altering the properties of extracellular matrix. https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153249924 2022-04-22 07:33:16 UTC https://padlet.com/yeszhanovagaukhar/no6pypmeptym5utt/wish/2153249924