Throughout the series, Teresa Agnes and Ava Paige frequently mention that WICKED is good, with Paige saying that saving the human race is worth the deaths of a few. Eventually, however, when no cure has been discovered after years of experiments, Teresa turns against WICKED, and Ava Paige is among the few remaining members of WICKED who oppose the idea of repeating the Trials (which would destroy what she had come to realize was the last remaining hope for the human race, the Immunes themselves).

WICKED's ultimate fate is unknown, although it is safe to assume that it is destroyed by the Right Arm during their attack in The Death Cure. After the attack, Paige writes an email to the other WICKED members saying that although WICKED has failed in their original attempt to find a cure, they have ultimately succeeded in their goal of saving the human race by sending the surviving Immunes to a safe place where they can start to rebuild civilization. In her opinion, WICKED is good