WISTAR KYOTO - NORMOTENSIVE YET DEPRESSIVE by https://padlet.com/17202317/nj8d38ak5bi57i85 Model of Endogenous Depression en-us 2022-04-03 03:29:38 UTC 2026-01-29 20:45:58 UTC hello@padlet.com Inbred or Outbred? 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126883237
  • The WISTAR KYOTO (WKY) strain is an inbred strain.
  • Derived from the same parental Wistar rats stock
    • ]]>     2022-04-03 03:40:23 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126883237     General Feature 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126883866
  • Albino rat 
  • Characterized by its wide head, long ears, and having a tail length that is always less than its body length
    • ]]>     2022-04-03 03:42:05 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126883866     Origin & History 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126884229 Why is it named as WISTAR KYOTO (WKY)? 
    • In 1960, Okamoto at Kyoto University selected Wistar rats based on expression of spontaneous hypertension Wistar animals with "normal" blood pressure (normotensive) selected to be used as same-genetic background of spontaneous hypertensive rats (SHR)

    In short;
    1. SHR: Wistar ancestor, hypertensive 
    2. WKY: Wistar ancestor, normotensive control for SHR 
    3. Wistar: Outbred albino rats 
    ]]>     2022-04-03 03:43:03 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126884229     Uses in Biomedical Research 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126884396 2022-04-03 03:43:32 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2126884396 Forced Swim Test (FST) 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2128957284
  • A rodent behavioral test to detect antidepressant activity. Depressive-like behavior will exhibit immobility  in inescapable container filled with water
    • ]]>     2022-04-04 15:58:12 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2128957284     Open Field Test (OFT) 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129281319
  • Simple sensorimotor test to determine general activity levels and gross locomotor activity in rodent of CNS disorders. 
  • WKY rats place in a square, white Plexiglas box.

    • Results:
    • Hypoactive, highly immobile in OFT
    • Suggest the presence of depressive behavior 
    ]]>     2022-04-04 18:48:00 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129281319     Taxonomy 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129334716 Scientific classification of Wistar Kyoto rats ]]> 2022-04-04 19:19:45 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129334716 Morphology Differences between Strains 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129364000 2022-04-04 19:40:04 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2129364000 Gender Differences and The Physiology 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2156693202 2022-04-25 14:45:50 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2156693202 Estrus Cycle and Behavioral Changes 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2156695768 *Other factor affecting vulnerability to stress in WKY female is ESTRUS CYCLE. Steriod hormone milieu in WKY rats may be responsible for these behavioral changes]]> 2022-04-25 14:47:07 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2156695768 What Is Wistar Kyoto Rats? Its Origin? Taxonomy? 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157655345 2022-04-26 01:57:09 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157655345 The Morphology 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157684928 2022-04-26 02:20:55 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157684928 Common Tests to Assess Physiological and Behavioral Changes 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157692144 2022-04-26 02:26:30 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157692144 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157699211 Depressive-like behaviour of WKY males was observed from early adolescence while female WKY, it appeared only in adulthood.]]> 2022-04-26 02:32:00 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157699211 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157699842 Female WKY rats are more vulnerable to chronic stress and stress induced behavioral depression than male rats]]> 2022-04-26 02:32:28 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157699842 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157701393 WKY female rats have progressively decreased in food consumption, whereas feeding WKY male rats returned to control levels after five stress days ]]> 2022-04-26 02:33:33 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157701393 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157701569 WKY females rats are more active in OFT, but more immobile in FST compared to WKY male rats ]]> 2022-04-26 02:33:39 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157701569 Stomach Ulcer Severity 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157709424 More pronounced during proestrus-estrus phase than diestrus phase ]]> 2022-04-26 02:39:47 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157709424 Open Field Test (OFT) 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157712299
  • Less active during proestrus-estrus than diestrus phase 
  • More emotional in OFT
    • ]]>     2022-04-26 02:42:22 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157712299     Forced Swim Test (FST) 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157713886
  • Significantly immobile during proestrus-estrus than diestrus phase 
  • Exhibiting more signs of behavioral depression in FST
    • ]]>     2022-04-26 02:43:48 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157713886     Used extensively in physiological studies relating to hypertension 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157735994 WKY serve as normotensive control for SHR strain. Both share same genetic background, from Wistar ancestor ]]> 2022-04-26 03:02:22 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157735994 Use to understand the neurobiology underlying anxiety and depression 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157737814 Genetic  model  of  depression,  displays  sex differences  in  response  to  antidepressants]]> 2022-04-26 03:03:50 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157737814 Animal model for treatment-resistant depression 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157739882 WKY rat appears to be insensitive to some common antidepressant compounds

    ]]>     2022-04-26 03:05:19 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157739882     May be useful model for development of personalized anti-depressant therapies for treatment resistant depression 17202317 https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157741778 WKY appears to be resistant in early life manipulations (neonatal handling) that are therapeutic in other strains]]> 2022-04-26 03:06:44 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2157741778 References https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2159040725 2022-04-26 18:11:43 UTC https://padlet.com/17202317/nj8d38ak5bi57i85/wish/2159040725