Cell Signaling Project by Tibin Zachariah https://padlet.com/1066489/ncohqjjhgfke Made by Eric Thomas, Karan Sidhu and Tibin Zachariah en-us 2017-09-25 04:46:19 UTC 2025-11-02 08:12:39 UTC hello@padlet.com Kidney Disease 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190671101 2017-09-25 04:49:26 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671101 Symptoms 1069941 https://padlet.com/1066489/ncohqjjhgfke/wish/190671366 2017-09-25 04:51:41 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671366 1069941 https://padlet.com/1066489/ncohqjjhgfke/wish/190671410
  • Loss of appetite 
  • Poor sleep 
  • Shortness of breath 
  • Vomiting 
  • Feeling tired/ no energy 
  • Urinating more often 

    • ]]>     2017-09-25 04:52:00 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671410     Caused By: 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190671463 2017-09-25 04:52:27 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671463 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190671491
  • Damaged kidneys 
  • Buildup of waste 
  • Uncontrolled blood sugar/pressure 

    • ]]>     2017-09-25 04:52:39 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671491     Healthy Kidney 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190671626
  • remove waste products from the body
  • remove drugs from the body
  • balance the body's fluids
  • release hormones that regulate blood pressure
  • produce an active form of vitamin D that promotes strong, healthy bones
  • control the production of red blood cells



    • ]]>     2017-09-25 04:53:26 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671626     Diseased Kidney 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190671653 has a granular surface, with decreased function, smaller size, and high urine protein levels 

    ]]>     2017-09-25 04:53:39 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190671653     Correct Mechanism: 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190674129 Kidney contains many nephrons that have a glomerulus connected via tubules
    Chemicals and water filtered as they pass through these tubules 
    Urine is the product that is passed through

    ]]>     2017-09-25 05:17:32 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190674129     Incorrect Mechanism: 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/190674374  Decreased Cell size 
    No cell division or cell growth occurs 
    Cysts present 
    hyperfilteration occurs due to the increased work seen by the glomeruli
     

    ]]>     2017-09-25 05:19:53 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/190674374     Organs Affected 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/191113746 the Brain and nervous system are affected mainly. The levels of Urea are increased when the kidneys do not work properly. Urea being toxic affects all of the systems in the body as well as the major organs. ]]> 2017-09-26 07:08:13 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/191113746 How Kidney is affected 1069941 https://padlet.com/1066489/ncohqjjhgfke/wish/191114495 CKD arises due to many pathological insults that affects the renal function and destroys some of the nephrons. As a result, the other nephrons compensate the function of injured nephrons by hyper filtration. Over a period of time, it develops glomerular hypertension, proteinuria, and eventually loss of renal function. An increase in the glomerular capillary pressure leads to the destruction of glomerular capillary wall which causes dysfunction. ]]> 2017-09-26 07:10:45 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/191114495 Cell Signaling Pathway 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/191120473 The Renin-angiotensis-aldosterone system (RAAS) is the cell signaling pathway that is involved in Chronic Kidney Disease. The ligand that is involved in the pathway is called Renin which is produced and released by the kidneys. ]]> 2017-09-26 07:34:49 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/191120473 Current Research 1069941 https://padlet.com/1066489/ncohqjjhgfke/wish/191122112 The only way to deal with Kidney disease is with dialysis or kidney transplant but those options can take a very long and are intensive.The Harvard Stem Cell Institute is developing new therapies to repair kidney damage, reducing the need for dialysis and transplantation. They will lower the need of kidney transplants and not be as intensive as dialysis.  ]]> 2017-09-26 07:41:12 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/191122112 Basics of Signal Transduction 1066489 https://padlet.com/1066489/ncohqjjhgfke/wish/191124693 The kidneys have to work a lot harder because of the damaged glomeruli due to the starting causes of CKD (diabetes, hypertension, etc). This over filtration process triggers the RAAS. The signal pathway starts after the kidneys release renin. Renin causes a protein to split which makes another enzyme be added. This all results in another protein being made and is what affects the kidneys and leads to CKD. ]]> 2017-09-26 07:49:38 UTC https://padlet.com/1066489/ncohqjjhgfke/wish/191124693