Lyme Disease Flowchart by Mary Flathers https://padlet.com/maryflathers/n6e87s1kjegi en-us 2018-02-28 20:33:11 UTC 2019-03-28 18:00:50 UTC hello@padlet.com A tick larvae (Ixodes scapularis: blacklegged tick) feeds on a rodent infected with the borrelia burgdorferi bacteria maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236726360 2018-03-01 00:10:09 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236726360 The bacteria reaches the midgut of the tick and stays there maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236727449 2018-03-01 00:17:22 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236727449 The bacteria in the midgut of the tick begins to multiply after ingesting the nutrients from the bloodmeal (relying on manganese) maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236758201 2018-03-01 03:00:45 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236758201 The bacteria then travels to the salivary glands of the tick maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236758269 2018-03-01 03:01:04 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236758269 The tick starts to feed on a human host maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759448 2018-03-01 03:08:13 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759448 B. burgdorferi is injected into the host during the bite (usually 36-48 hours) maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759655 2018-03-01 03:09:34 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759655 Once in the host, the spiral-shaped bacteria travels through the bloodstream to infect many different parts of the body maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759854 2018-03-01 03:10:34 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236759854 B. burgdorferi is extremely effective at disguising itself from the immune system maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236760829 2018-03-01 03:17:00 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236760829 A certain protein (Salp15) in the tick's saliva repress the immediate immune response an inhibits the mobilization and activation on antigen-presenting cells. Also, downregulation of cathelidicin + defensin furthermore helps to allow the bacteria to enter the body undetected to the immune cells for up to a few weeks maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236761990 2018-03-01 03:23:54 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236761990 Once the body realizes that the bacteria is a threat, it tries to attack it, but can't. Instead, the body has an inflammatory response which damages tissues. maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236762180 2018-03-01 03:25:03 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236762180 The bacteria can also change which proteins are on the outermost layer of the cell, causing it to be seen as familiar (a fit) to cell receptors maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236762574 2018-03-01 03:27:21 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236762574 The bacteria can form a biofilm, which is a protein barrier that protects the bacteria from the immune cells or antibiotics maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236763096 2018-03-01 03:30:08 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236763096 Because of their shape, the bacteria can push their way into cells (specifically cells in the nervous and cardiovascular systems and the joints) maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236763791 2018-03-01 03:33:53 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236763791 This causes many of the symptoms of the disease maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236765354 2018-03-01 03:42:20 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236765354 Even with treatment, symptoms can still be present because the bacteria could be surviving in hard to access areas, like the joints maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236765470 2018-03-01 03:42:59 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236765470 -Use tick repellent -See doctor immediately if bitten by a tick -Wear long clothing and avoid forest and bushes maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236767401 2018-03-01 03:53:49 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236767401 Go to a doctor for different treatment options (ex: antibiotic) maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/236767594 2018-03-01 03:55:16 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/236767594 The bacteria relies on manganese to fuel itself and preform tasks instead of iron, the primary source of nutrients for many other bacteria dannyciccarello https://padlet.com/maryflathers/n6e87s1kjegi/wish/238371457 2018-03-05 21:45:25 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/238371457 Starve the bacteria of manganese dannyciccarello https://padlet.com/maryflathers/n6e87s1kjegi/wish/238392546 2018-03-05 23:08:37 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/238392546 A potential drug that breaks down the biofilm maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/238393175 2018-03-05 23:12:30 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/238393175 blue = pathogenesis maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004519 2018-03-07 05:47:52 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004519 green = a way the bacteria escapes the immune system maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004582 2018-03-07 05:48:24 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004582 red = an intervention maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004599 2018-03-07 05:48:39 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/239004599 Take a Lyme Disease Antibiotic: Doxycycline (a bactericidal drug - prevents cell wall synthesis), Amoxicillin (a bactericidal drug - prevents cell wall synthesis), or Cefuroxime Axetil (a bacteriostatic drug - prevents protein synthesis) maryflathers https://padlet.com/maryflathers/n6e87s1kjegi/wish/239006685 2018-03-07 06:07:26 UTC https://padlet.com/maryflathers/n6e87s1kjegi/wish/239006685