Diseases: Nature or Nurture? by Alice Meyer https://padlet.com/ameyer17/n04qmjvah0qp Consider the following diseases and, in pairs, look up your assigned disorder. On this padlet, make a sticky note answering the following questions: Name of disease: Discuss what scientists think causes this disease. Would this cause be nature or nurture (or some combination). Give an interesting fact or two you learned about the disease. (1) Huntington's Corea: (2)Tay-Sachs: (3)Cerebral Palsy: (4)PKU (5)Sickle-Cell Anemia en-us 2016-09-06 21:18:08 UTC 2026-02-23 09:59:07 UTC hello@padlet.com Huntingtons Disease  https://padlet.com/ameyer17/n04qmjvah0qp/wish/125562237 This disease is "like having Alzheimer's, Parkinson's and ALS, simultaneously." Over time it affects individuals ability to walk, reason and speak. It is entirely genetic. Children whose parents have Huntington's Disease have a 50/50 chance of getting it. ]]> 2016-09-21 20:43:55 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125562237 Hemophilia https://padlet.com/ameyer17/n04qmjvah0qp/wish/125564038 What are the details that make this a genetic disease?  (dominant or recessive? which chromosome? other details?)
 
It is genetic and can be passed down to offspring but 1 in 3 cases occur due to a spontaneous mutation. It is inherited through the X protein in an inherited manner. 
 
What are the symptoms?

Bleed longer than most people, bleeds can occur internally. 

Is this disease treatable?  How? 

Yes, by taking a clotting factor that’s infused either through a vein in the arm or a port in the chest. 
 
Interesting fact you learned?

One in every 5,000 people is born with hemophilia 
]]> 2016-09-21 20:58:01 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125564038 PKU https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596441 1. What are the details that make this a genetic disease?  (dominant or recessive? which chromosome? other details?) :
In the infant body, there is a build up of phenylalanine which causes brain damage due to the genetic mutation. The enzyme that normally breaks down phenylalanine is not present due to the mutation. This is a recessive trait. If one parent has it, it can be passed down. It is found on chromosome 12

2. What are the symptoms?
Symptoms include seizures, tremors, hyperactivity, stunted growth, and eczema, or other skin conditions.

3. Is this disease treatable?  How? 
The disease is diagnosed through a screening test; often within weeks or months of birth. The way to treat this disease is through a specific diet; limiting foods containing the phenylalaninic enzyme. Another way is prescribed medication. Avoidance of breast milk during first years is critical, due to the high presence of the enzyme. At older ages, foods are limited to those with low protein content, such as eggs, milk, chicken etc.

4. Interesting fact you learned?
Treatment guidelines recommend beginning treatment as early as possible, starting dietary treatment within the first week of life.
]]> 2016-09-22 02:32:27 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596441 Sickle-Cell https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596443 If a child has one parent with hemoglobin S, and one parent with a normal hemoglobin gene, they will have sickle cell trait, which doesn't affect them, but if they have a child with another person who has the sickle cell trait, then their child is able to get sickle cell disease.
Symptoms: Abnormal brake down of red blood cells, delayed development, sudden pains in chest, yellow skin and eyes.
Treatable: This disease cannot be cured, but it can be treated through medications, blood transfusions, and rarely a bone-marrow transplant.
Interesting Fact: Twenty-five years ago, a person with sickle cell disease was not expected to live to adulthood, and the average life span was 21 years.

]]> 2016-09-22 02:32:28 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596443 Down Syndrome https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596520 This disease is neither dominant or recessive, rather it arises from abnormal cell division and creates extra genetic material that affects chromosome 21. It happens randomly during cell division early in fetal development. There are three types of Down Syndrome: Trisomy (most common), Mosaic, and Translocation. Symptoms included, delayed development, learning disability, lazy eye, flattened face, difficulty thinking and understanding, hearing loss, congenital heart disease, and impulsive behavior. Although Down Syndrome does not have a cure some symptoms are treatable through Speech, Occupational, and Physical therapy, glasses, and many other treatments. An interesting thing that we learned was that just 33 years ago, the average life expectancy of a person with Down Syndrome was 25-years-old. Today, it’s 60.]]> 2016-09-22 02:33:26 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125596520 Tay Sachs https://padlet.com/ameyer17/n04qmjvah0qp/wish/125600122 What are the details that make this a genetic disease?  A genetic mutation in the HEXA gene on chromosome 15. Occurs when there is build up to toxic levels in the child's brain which affect the nerve cells.
What are the symptoms? The child's body loses function, leading to blindness, deafness, paralysis and death.

Is this disease treatable?  How?  Not really treatable however Gene therapy or enzyme replacement therapy research may eventually lead to a cure.

Interesting fact you learned? Both parents must be carriers of the gene for it to be passed on, and even then there is a 3/4 chance you won't get it. ]]> 2016-09-22 03:08:05 UTC https://padlet.com/ameyer17/n04qmjvah0qp/wish/125600122