Adult stem cells - Health B (NB) by LYNSAY KOBELIS https://padlet.com/lynsay_kobelis/mzzgafiiewnd en-us 2019-09-19 21:03:31 UTC 2025-10-31 12:16:37 UTC hello@padlet.com Can become any blood cell - red, white, platelet lynsay_kobelis https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387243748 2019-09-20 15:03:18 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387243748 lynsay_kobelis https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387245501 2019-09-20 15:05:41 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387245501 cells are multipotent https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387246038 2019-09-20 15:06:28 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387246038 Mammary stem cells are multipotent adult stem cells that reside in the mammary gland, can self-renew by dividing and can differentiate into all specialised mammary epithelial cells. Mammary stem cells drive the development of the mammary gland during puberty and are responsible for its expansion during pregnancy. https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387246619 2019-09-20 15:07:09 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387246619 Found in peripheral blood and the bone marrow 4250891 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387247788 2019-09-20 15:08:47 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387247788 https://www.nature.com/subjects/mammary-stem-cells https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387247789 2019-09-20 15:08:47 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387247789 lynsay_kobelis https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387248324 2019-09-20 15:09:36 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387248324 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387249226 Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and differentiate into the specialised cells of the intestinal epithelium, which renews throughout life.]]> 2019-09-20 15:10:57 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387249226 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387249497 Are multipotent adult stem cells]]> 2019-09-20 15:11:21 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387249497 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250150 The intestinal epithelium is a single layer of cells organized into crypts and villi, known as the most rapidly self-renewing tissue in adult mammals. The cells that line the intestinal lumen perform the primary functions of digestion, water and nutrient absorption, and forms a barrier against luminal pathogens.]]> 2019-09-20 15:12:12 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250150 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250280 https://pituitary.org/item/olfactory-cells]]> 2019-09-20 15:12:24 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250280 60095751 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250662 https://ars.els-cdn.com/content/image/3-s2.0-B9780323396325000232-f23-05-9780323396325.jpg]]> 2019-09-20 15:12:54 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250662 The term 'mammary' relates to the breasts, specifically the milk glands in the breasts 4250891 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250664 2019-09-20 15:12:54 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250664 Olfactory receptors (ORs), also known as odorant receptors, are expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants (i.e., compounds that have an odor) which give rise to the sense of smell. https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250686 2019-09-20 15:12:55 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387250686 Mammary stem cells are found in the mammary gland in the breast https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251038 2019-09-20 15:13:21 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251038 The stem cells that form blood and immune cells are known as hematopoietic stem cells (HSCs). They are ultimately responsible for the constant renewal of blood—the production of billions of new blood cells each day. https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251707 2019-09-20 15:14:18 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251707 https://www.verywellhealth.com/epithelial-cells-definition-430052 4250891 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251718 2019-09-20 15:14:19 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387251718 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387252093 As with most glandular tissues, the adult mammary gland is composed of multiple cell types, including epithelial, adipose, fibroblasts, immune, lymphatic and vascular cells, that work together to sculpt and maintain a functional organ. These different cell types have been demonstrated to be of importance at specific stages of mammary gland development.]]> 2019-09-20 15:14:52 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387252093 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387252198 2019-09-20 15:15:00 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387252198 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253011 2019-09-20 15:16:15 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253011 Intestinal epithelial cells (IECs) line the surface of intestinal epithelium, where they play important roles in the digestion of food, absorption of nutrients, and protection of the human body from microbial infections, and others. 4250891 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253036 2019-09-20 15:16:18 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253036 https://www.ncbi.nlm.nih.gov/pubmed/21535908 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253456 2019-09-20 15:16:57 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387253456 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387254493 2019-09-20 15:18:39 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387254493 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387254740 https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1021]]> 2019-09-20 15:18:58 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387254740 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255286 2019-09-20 15:19:41 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255286 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255337 http://www.bloodjournal.org/content/131/5/479]]> 2019-09-20 15:19:46 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255337 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255839 2019-09-20 15:20:38 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255839 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255842 https://youtu.be/pl1sb_S78LA]]> 2019-09-20 15:20:38 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387255842 Mammary stem cells in mice https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387256825 https://jcs.biologists.org/content/118/16/3585]]> 2019-09-20 15:21:53 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387256825 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387256914 http://cdn.sci-news.com/images/enlarge4/image_5981e-Stem-Cell-Regeneration.jpg]]> 2019-09-20 15:21:59 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387256914 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257133 There are two types of hematopoietic cell transplantation, autologous and allogeneic. An autologous hematopoietic cell transplant uses a patient's own bone marrow or blood.]]> 2019-09-20 15:22:18 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257133 http://www.d.umn.edu/~jfitzake/Lectures/DMED/SensoryPhysiology/Olfaction/OlfactoryEpithelia.html https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257242 2019-09-20 15:22:28 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257242 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257534 The olfactory epithelium (OE) of vertebrates is a highly regenerative neuroepithelium that is maintained under normal conditions by a population of stem and progenitor cells, globose basal cells (GBCs), which also contribute to epithelial reconstitution after injury. However, aging of the OE often leads to neurogenic exhaustion, the disappearance of both GBCs and olfactory sensory neurons (OSNs). Aneuronal tissue may remain as olfactory, with an uninterrupted sheet of apically arrayed microvillar-capped sustentacular cell, or may undergo respiratory metaplasia. We have generated a transgenic mouse model for neurogenic exhaustion using olfactory marker protein-driven Tet-off regulation of the A subunit of Diphtheria toxin such that the death of mature OSNs is accelerated. At as early as 2 months of age, the epithelium of transgenic mice, regardless of sex, recapitulates what is seen in the aged OE of humans and rodents. Areas of the epithelium completely lack neurons and GBCs; whereas the horizontal basal cells, a reserve stem cell population, show no evidence of activation. Surprisingly, other areas that were olfactory undergo respiratory metaplasia. The impact of accelerated neuronal death and reduced innervation on the olfactory bulb (OB) was also examined. Constant neuronal turnover leaves glomeruli shrunken and affects the dopaminergic interneurons in the periglomerular layer. Moreover, the acceleration of OSN death can be reversed in those areas where some GBCs persist. However, the projection onto the OB recovers incompletely and the reinnervated glomeruli are markedly altered. Therefore, the capacity for OE regeneration is tempered when GBCs disappear.SIGNIFICANCE STATEMENT A large percentage of humans lose or suffer a significant decline in olfactory function as they age. Therefore, quality of life suffers and safety and nutritional status are put at risk. With age, the OE apparently becomes incapable of fully maintaining the neuronal population of the epithelium despite its well known capacity for recovering from most forms of injury when younger. Efforts to identify the mechanism by which olfactory neurogenesis becomes exhausted with age require a powerful model for accelerating age-related tissue pathology. The current OMP-tTA;TetO-DTA transgenic mouse model, in which olfactory neurons die when they reach maturity and accelerated death can be aborted to assess the capacity for structural recovery, satisfies that need.


]]> 2019-09-20 15:22:55 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257534 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257886 https://swissmedica.startstemcells.com/lp4/?utm_source=GoogleAdsEN&utm_medium=Search_Stemcells_Artilleria&utm_campaign=stem-cells&utm_content=168744658041&utm_term=%2Bstem%20%2Bcell]]> 2019-09-20 15:23:26 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387257886 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387259212 Intestinal epithelial cells (IECs) line the surface of intestinal epithelium, where they play important roles in the digestion of food, absorption of nutrients, and protection of the human body from microbial infections, and others.]]> 2019-09-20 15:25:21 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387259212 Adult neurogenesis https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387259237 https://www.embopress.org/doi/10.15252/embj.201798791]]> 2019-09-20 15:25:24 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387259237 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261012 Cognitive problems are a significant, persistent concern for patients undergoing hematopoietic stem cell]]> 2019-09-20 15:28:12 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261012 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261403 Thomas' research strongly supported the existence of hematopoietic stem cells as well. Thomas and his team discovered through work in dogs that there were specific cells in bone marrow that could restore hematopoiesis after lethal irradiation.]]> 2019-09-20 15:28:46 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261403 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261432 2019-09-20 15:28:48 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261432 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261500 Hematopoietic stem cell transplants are now routinely used to treat patients with cancers and other disorders of the blood and immune systems. Recently, researchers have observed in animal studies that hematopoietic stem cells appear to be able to form other kinds of cells, such as muscle, blood vessels, and bone.]]> 2019-09-20 15:28:55 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261500 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261824 2019-09-20 15:29:10 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387261824 Scroll down the website for stem cells specifically https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387262150 http://genesdev.cshlp.org/content/22/14/1856.full]]> 2019-09-20 15:29:36 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387262150 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263192 2019-09-20 15:31:18 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263192 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263213 https://www.thermofisher.com/uk/en/home/life-science/stem-cell-research/hematopoietic-stem-cells.html?ef_id=EAIaIQobChMIufLn_Nvf5AIVhbHtCh1arg4kEAAYASAAEgIaSvD_BwE:G:s&s_kwcid=AL!3652!3!367765480926!e!!g!!hematopoietic%20cells&gclid=EAIaIQobChMIufLn_Nvf5AIVhbHtCh1arg4kEAAYASAAEgIaSvD_BwE]]> 2019-09-20 15:31:19 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263213 Intestinal stem cells (ISCs) are the only dividing cells in the intestinal epithelium that can give rise to at least two differentiated intestinal cell types: enteroendocrine cells and enterocytes. https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263850 2019-09-20 15:32:24 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387263850 https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387264147 https://www.nature.com/subjects/intestinal-stem-cells]]> 2019-09-20 15:32:52 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387264147 Why are they needed? https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387264713 The intestinal epithelium is a rapidly renewing cellular compartment. This constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (ISC) proliferation and differentiation. The intestine also meets pathogenic environmental factors that means it must actively repair  constantly]]> 2019-09-20 15:33:34 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387264713 https://www.sciencedirect.com/science/article/pii/S193459091100110X https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387266015 2019-09-20 15:35:39 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387266015 Teratoma tumours https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387269096 Is a teratoma a baby?
Sacrococcygeal teratoma (SCT) is a tumor that develops before birth and grows from a baby's coccyx — more commonly known as the tailbone. It is the most common tumor found in newborns, occurring in 1 out of every 35,000 to 40,000 live births.
]]> 2019-09-20 15:40:30 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387269096 Mammary stem cells role in helping suppress teratomas https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387270269 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223207/]]> 2019-09-20 15:42:16 UTC https://padlet.com/lynsay_kobelis/mzzgafiiewnd/wish/387270269