Advanced Cancer Case #2 by Muhammet https://padlet.com/mfmdna/advcancerc2 Hematuria en-us 2018-03-12 10:20:29 UTC 2018-03-19 10:52:13 UTC hello@padlet.com Facts mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240764610 56 year-old female (age risk)
  • the recommended age to start yearly cancer screening for women is 50-64 years particularly breast cancer, cervical cancer, colon cancer, lung cancer screening tests. bladder cancer screening is not common.
no family history of hematuria
smokes 1pack/day (20pack/year)
Has been working at a Dye factoy for the last 20 years
Gross Hematuria
no pathological findings
no biochemical/microbiological findings
any general medication?
physical exam results?
no fever or inflammation
]]> 2018-03-12 10:26:10 UTC https://padlet.com/mfmdna/advcancerc2/wish/240764610 Hypotheses mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240767317 bladder cancer
  • bladder cancer occurence age range is 38-79, w/ mean of 56.5
  • although statistically low chance, bladder cancer has occured among workers at dye factories
urine infection  x
kidney stones   x
menstrual history
genital system infection x
glomerulo nefrit x
liver problems x
hemolytic anemia x
kidney trauma x
medication side effects?
endometriosis
ovarian cancer

]]> 2018-03-12 10:34:51 UTC https://padlet.com/mfmdna/advcancerc2/wish/240767317 Part 2 facts mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240768390 Tests:
  • urinary cytology
  • cytourethroscopy
  • upper urinary tract imaging
Results:
lesions in bladder
TCC in biopsies 4/10
]]> 2018-03-12 10:38:14 UTC https://padlet.com/mfmdna/advcancerc2/wish/240768390 TCC mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240770667 Transitional Cell Carcinoma
  • epithelial cell from urinary tract/bladder
  • TCC markers:
predisposition in patients w/ abberations in p21, p53, over expression of EGFR and Her2, microsattelite and chr 9 instability
?primary or secondary
?could non-TCC 6/10 cells be in situ carcinoma
TCC TNM staging


]]> 2018-03-12 10:45:22 UTC https://padlet.com/mfmdna/advcancerc2/wish/240770667 secondary cancer? mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240774079 2018-03-12 10:57:01 UTC https://padlet.com/mfmdna/advcancerc2/wish/240774079 primary cancer? mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240776733 lymph nodes, bones, lungs, liver, and peritoneum are the most common sites of metastasis from bladder cancer. The lymph nodes are the most common site of metastasis from bladder cancer.]]> 2018-03-12 11:06:33 UTC https://padlet.com/mfmdna/advcancerc2/wish/240776733 Possible Causes of TCC and Mechanism mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240780927 smoking
factory dyes]]> 2018-03-12 11:20:19 UTC https://padlet.com/mfmdna/advcancerc2/wish/240780927 Primary Tumor Reasoning mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240782256 since the detected cells are TCC cells the cancer could have only metastasized from nearby transitional cells  from the ureter, kidney or bladder]]> 2018-03-12 11:24:37 UTC https://padlet.com/mfmdna/advcancerc2/wish/240782256 Learning Objectives mfmdna https://padlet.com/mfmdna/advcancerc2/wish/240784299
  • What is TCC?
  • What are the types of bladder cancers?
  • How can we differentiate TCC from others?
  • What is the histology and phsiyology of bladder?
  • What are the mechanisms of TCC and what are the criteria for diagnosis of TCC (macro/micro)
  • How do occupational risk factors cause bladder cancer?
  • Smokers bladder cancer risk and why bladder?
  • What is the standard protocol on diagnosing TCC, why 10 biopsies?
  • How is that smoking and factory dyes cause bladder cancer? how are chemicals from smoking or dye initiate the cancer? How are they metabolized in body before they reach the bladder?
  • How are the chemicals carcinogenic? are they directly carcinogenic or the metabolites derived from the liver carcinogenic?
    • ]]>     2018-03-12 11:30:44 UTC https://padlet.com/mfmdna/advcancerc2/wish/240784299     Mechanisms mfmdna https://padlet.com/mfmdna/advcancerc2/wish/243370464 2018-03-19 09:16:10 UTC https://padlet.com/mfmdna/advcancerc2/wish/243370464 Phsiyology of the bladder mfmdna https://padlet.com/mfmdna/advcancerc2/wish/243378600 2018-03-19 09:41:51 UTC https://padlet.com/mfmdna/advcancerc2/wish/243378600 Criteria for TCC Diagnosis mfmdna https://padlet.com/mfmdna/advcancerc2/wish/243391816 cytoscopy + histology]]> 2018-03-19 10:24:08 UTC https://padlet.com/mfmdna/advcancerc2/wish/243391816 sfdsgfds mfmdna https://padlet.com/mfmdna/advcancerc2/wish/243398734 https://www.cancer.net/cancer-types/bladder-cancer/introduction
    https://www.texasoncology.com/types-of-cancer/bladder-cancer/stage-0-bladder-cancer
    https://www.google.com.tr/search?q=transitional+epithelium&rlz=1C1NHXL_trTR720TR720&oq=transitional+ep&aqs=chrome.0.0j69i57j0l4.10116j0j7&sourceid=chrome&ie=UTF-8
    microsatellite instability

    ]]>     2018-03-19 10:46:35 UTC https://padlet.com/mfmdna/advcancerc2/wish/243398734