Placenta-on-a-Chip Determines Pregnancy-safe Drugs by Sindhu Koickel, BSN, RN https://padlet.com/sindhu_koickel/momd2jr5e0av Researchers at the University of Pennsylvania have created a microfluidic chip that mimics the placenta, which can be used to test for pregnancy-safe drugs. en-us 2018-02-25 23:28:21 UTC 2023-03-07 07:32:25 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Babyhead.png Summary sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235167346 Drugs are categorized based on risk to the fetus.  Many drugs are placed in Category C; meaning not enough research has been done to determine if the drugs are safe.  It is currently unknown how the placenta allows some molecules and not others.  There are several drugs that are medically necessary for pregnant mothers but pose a risk to the fetus, thereby placing the mother at risk for medical complications. ]]> 2018-02-25 23:38:25 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235167346 Pros sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235168087 This technology would be extremely helpful assessing drug safety for pregnant women. This is especially helpful to those who are taking medications that are medically necessary, keeping both mother and baby safe from harm.
This research is just one of the many doors being opened for 'organs-on-a-chip' that will be used for drug testing in various areas of medicine. ]]> 2018-02-25 23:43:16 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235168087 Cons sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235168530 Due to the risk of affecting fetuses, this technology cannot be tested on pregnant mothers. Donated placentas are being used but are only viable for a few hours. This could create difficulty in collecting accurate data. ]]> 2018-02-25 23:46:21 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235168530 Opinion sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235169344 This is a great step toward a breakthrough, as many pregnant women suffer through medical complications due to halting a medically necessary medication, that may cause risk to the fetus. I have personally gone through this with migraine medication while pregnant. As a nurse in psychiatry, I had pregnant patients who couldn't take their psychiatric drugs due to this issue, which imposed a different risk to the mother and fetus altogether. ]]> 2018-02-25 23:51:46 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235169344 Source details sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235170040 Bloomberg. (2015, July 29). 

Drug testing shake up with organs-on-a-chip. Retrieved from https://www.youtube.com/watch?v=rI8piLXJawQ&t=3s


Brusie, Chaunie. (2015, August 19). Pregnancy: Category C drugs you should avoid. Retrieved from 

https://www.healthline.com/health/pregnancy/category-c-drugs#


Lerner, Evan. (2016, July 21). 

Penn researchers develop placenta-on-a-chip. Retrieved from https://news.upenn.edu/news/penn-researchers-develop-placenta-chip

]]> 2018-02-25 23:57:09 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235170040 sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235171816 2018-02-26 00:12:22 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235171816 sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235171998 2018-02-26 00:13:33 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235171998 Integrating Nursing Informatics sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235182812 As this technology advances and is implemented, nurses may use this to educate and integrate this into their evidence-based practice.
There may also be nurses involved in the research itself by collecting and analyzing data. They may also design and develop methods to integrate the technology into patient-focused care.]]> 2018-02-26 01:24:43 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235182812 Drug Testing Shake Up with Organs-on-a-Chip sindhu_koickel https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235186633 Bloomberg
Published on Jul 29, 2015]]> 2018-02-26 01:47:05 UTC https://padlet.com/sindhu_koickel/momd2jr5e0av/wish/235186633