Nykell & Alexis: Law of Bergonie & Tribondeau Mind map by https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l Radiosensitivity basics en-us 2020-06-16 21:27:35 UTC 2026-02-14 17:33:43 UTC hello@padlet.com alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608978 2020-06-16 21:27:35 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608978 Function of metabolic state alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608979 High metabolism = radiosensitive]]> 2020-06-16 21:27:35 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608979 Directly proportional to reproductive activity alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608980 The relationship shared between reproductive activity and radiosensitive is a liner one. A cell of frequent reproductive activity is more vulnerable to ionizing radiation sensitivity. ]]> 2020-06-16 21:27:35 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608980 Inversely proportional to degree of differentiation alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608981 The more specialized a cell is, the more sensitive it will be to ionizing radiation. Therefore the relationship between degree of differentiation and dose is an inverse one. ]]> 2020-06-16 21:27:35 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608981 Inversely proportional to age alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608982 As cells age and become more mature their susceptibility to damaged caused by ionizing radiation lessens.  

]]> 2020-06-16 21:27:35 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/629608982 Blood Cells/System nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631167946 Includes bone marrow, circulating blood, and lymph tissue]]> 2020-06-17 20:26:46 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631167946 Most Radiosensitive --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------> Least Radiosensitive nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631205916 2020-06-17 21:04:47 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631205916 Epithelial Tissue nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631232186 Includes the lining of GI tract, respiratory tract, and blood vessels as well as the skin on outside of body]]> 2020-06-17 21:32:57 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631232186 Muscle and Nerve Cells nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631240182 2020-06-17 21:41:41 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631240182 Reproductive/Sex Cells nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631241690 Includes spermatogonia and ova]]> 2020-06-17 21:43:24 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631241690 nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631246553 Most















































Least]]> 2020-06-17 21:49:19 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631246553 Lymphocytes nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631247622
  • Live for 24 hours, making them highly radiosensitive 
  • 0.25 Gy decreases the count while 0.5-1.0 Gy drops the count to 0
  • At lower levels of Gy, the blood cell recovers shortly after irradiation, higher doses requires several months for recovery
    • ]]>     2020-06-17 21:50:34 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631247622     Granulocytes nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631257677
  • Live for less than 1 week
  • After exposure they increase in #, then rapidly drop, then slower drop in #
  • Recovery is about 2 months
    • ]]>     2020-06-17 22:03:01 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631257677     Thrombocytes & Neutrophils nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631261144
  • 0.5 Gy decreases these numbers
  • Slow recover -can be up to 2 months
  • Thrombocytes have a life span of 30 days
    • ]]>     2020-06-17 22:08:01 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631261144     Erythrocytes nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631263736
  • Longest life span of blood cells, making them the least radiosensitive (120 days)
  • Once irradiated, the decrease in numbers may not be apparent for weeks 
  • Recovery takes months
    • ]]>     2020-06-17 22:11:04 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631263736     Spermatogonia nykellmogensen https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631265486
  • Immature = highly radiosensitive
  • Mature = relatively insensitive 
  • 1 Gy dose decreases sperm count & creates the potential for genetic mutations
  • 2 Gy dose temporary sterility for up to 12 months
  • 5-6 Gy dose = Permanent sterility
    • ]]>     2020-06-17 22:13:29 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631265486     alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631288726
  • Devoid of blood vessels 
  • Constantly regenerated through mitosis
  • 50% renewal of Intestinal lining occurs each day
    • ]]>     2020-06-17 22:45:25 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631288726     Nerves alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631293291
  • Immature embryo-fetus =  radiosensitive 
  • maximum window of sensitivity = 8-15 weeks following gestation
  •  Sensitivity levels drop after the 25th week, sensitivity considered = to adults
  • Adult nerve cells are highly & non-dividing specialized = insensitive 
  • Damage to the dendrites or axon results in impaired function
  • Dose > than 50 Gy delivered to the nucleus causes cell death 
    • ]]>     2020-06-17 22:51:49 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631293291     Muscle Tissue alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631307178
  • Don't divide, highly specialized movement functions = radioresistant 
    • ]]>     2020-06-17 23:12:01 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631307178     Ova alexisschneider1 https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631312883
  • Fetus- child = very sensitive
  • mature Ova = least sensitive at ages 20-30 yrs
  •  Irregular mensuration occurs at .1 Gy
  • Temporary sterility = 2Gy w/ a recovery period of several weeks
  • Permanent sterility occurs at a single dose of 5 Gy
    • ]]>     2020-06-17 23:20:21 UTC https://padlet.com/alexisschneider1/m6bcbr3o5cg1zg2l/wish/631312883