-Is well tolerated and has less side effects then ACE inhibitors

-Also referred to as angiotensin II blockers

Valsartan (Diovan)

Irbesartan (Avapro)

Candesartan (Atacand)

Olmesartan (Benicar)

Telmisartan (Micardis)

Eprosartan (Teveten)

• pregnancy

-Can cause fetal toxicity, avoid breastfeeding

1. Hyperkalemia is more likely to occur than when using ACE inhibitors.

2. Cough is more likely to occur than when using ACE inhibitors.

3. Chest pain is a common adverse effect.

4. Overdose is usually manifested by hypertension and bradycardia.

The most common adverse effects of ARBs are chest pain, fatigue, hypoglycemia, diarrhea, urinary tract infection, anemia, and weakness. Hyperkalemia and cough are less likely to occur than with the ACE inhibitors.

Overdose may manifest as hypotension and tachycardia; bradycardia occurs less often. Treatment is symptomatic and supportive and includes the administration of IV fluids to expand the blood volume.

1. Losartan - hypertension, kidney protection in diabetes.

2. Valsartan - hypertension, heart failure.

3. Irbesartan - hypertension, diabetic nephropathy.

-Avoid potassium supplements