https://padlet.com/jmtforvalue1/kxmn6cngpoa8 Made with no regrets, whatsoever en-us 2019-03-01 14:52:18 UTC 2019-03-01 15:38:03 UTC hello@padlet.com jmtforvalue1 https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336867427 2019-03-01 14:58:44 UTC https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336867427 jmtforvalue1 https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336867654 2019-03-01 14:59:15 UTC https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336867654 jmtforvalue1 https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336876728 Genetics
Hereditary non-polyposis colorectal cancer accounts for two to seven per cent of cases of colorectal cancer.
The risk of an individual developing hereditary non-polyposis colorectal cancer is increased by mutations in a set of genes normally responsible for repairing DNA.
Only one inherited copy of a mutated gene is sufficient to raise an individual’s risk of cancer?.
Mutations in the MLH1, MSH2, MSH6 or PMS2 genes all increase an individual's risk of developing hereditary non-polyposis colorectal cancer.
Mutations in the MSH2 and MLH1 genes are most common (90 per cent of cases).
Mutations in the EPCAM gene can also indirectly increase an individual’s risk of developing the disorder. The EPCAM gene lies next to the gene MSH2 on chromosome? 2 and some mutations in the EPCAM gene can switch the MSH2 gene off.
Hereditary non-polyposis colorectal cancer also increases the risk of other cancer types including cancers of the ovary, stomach, small intestine, brain and skin.
Biology
The genes MLH1, MSH2, MSH6 and PMS2 are all involved in repairing the mistakes that occur when DNA is copied in preparation for cell division?.
Mutations in these genes mean that mistakes made during DNA replication? are not properly repaired and the cells continue to divide, copying the mistakes over and over.
This can then lead to uncontrolled cell growth and possibly cancer.
However, not all individuals with these mutations will develop cancerous tumours.]]> 2019-03-01 15:17:57 UTC https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336876728 jmtforvalue1 https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336879665 2019-03-01 15:23:04 UTC https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336879665 jmtforvalue1 https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336882075 2019-03-01 15:27:17 UTC https://padlet.com/jmtforvalue1/kxmn6cngpoa8/wish/336882075