They continue toward the homestead, intending to return to the gas station once it has received a fuel delivery. When they arrive, Franklin tells Kirk and Pam about a local swimming hole, and the couple go to find it. They stumble upon a nearby house, and Kirk calls out for gas, entering through the unlocked door, while Pam waits outside. Leatherface, a large mute man wearing a mask made from human skin, suddenly appears and kills Kirk with a hammer. Pam enters soon after and trips into a room filled with furniture made from human bones. She attempts to flee, but Leatherface catches her and impales her on a meathook, making her watch as he butchers Kirk with a chainsaw. Jerry heads out to look for Pam and Kirk at sunset. He sees the house and finds Pam, still alive, inside a freezer. Before he can react, Leatherface kills him.

With darkness falling, Sally and Franklin set out to find their friends. As they near the neighboring house and call out, Leatherface lunges from the darkness and kills Franklin with a chainsaw. Sally runs toward the house and finds the desiccated remains of an elderly couple upstairs. She escapes from Leatherface by jumping through a second-floor window, and she flees to the gas station. The proprietor calms her with offers of help, but then he ties her up, gags her, and forces her into his truck. He drives to the house, arriving at the same time as the hitchhiker, now revealed as Leatherface's brother. The hitchhiker recognizes Sally and taunts her.

The men torment the bound and gagged Sally while Leatherface, now dressed as a woman, serves dinner. Leatherface and the hitchhiker bring down one of the desiccated bodies from upstairs, that of their Grandpa. He is revealed to be alive when he sucks blood from a cut on Sally's finger. They decide that Grandpa, the best killer in the old slaughterhouse, should kill Sally. He tries to hit her with a hammer, but he is too weak. In the ensuing struggle, she breaks free, leaps through a window, and flees to the road. Leatherface and the hitchhiker give chase, but the latter is run over and killed by a passing truck. Leatherface attacks the truck with his chainsaw, and, when the driver stops to help, he knocks Leatherface down with a pipe wrench, causing the chainsaw to cut his leg. The driver flees, and Sally escapes in the back of a passing pickup truck as Leatherface maniacally flails his chainsaw in the air in anger and defeat.

Hanson calls border patrol on them before he sees the cartel coming up. He ends the call and gets involved in a shootout with the cartel led by Mauricio. Hanson shoots and kills Mauricio's brother; Rosa is fatally wounded by one of the cartel members. Before she dies, she gives Hanson a note that lists her family's address in Chicago. Hanson reluctantly agrees to take Miguel to her family in Chicago.

Border patrol show up after her death and take in Miguel. One of the cartel members comes in and claims that he's a relative of Miguel. Hanson happens to see their car there and sneaks Miguel out to go to Chicago.

The cartel use fake passports to get into America to follow Hanson and Miguel. A corrupt border patrol officer sees their gang tattoos, recognizes that the passports are fake, and allows them in anyway.

After Hanson uses his credit card to repair his truck, Mauricio tracks the pair to Route 66 in Oklahoma. A corrupt cop follows Hanson and Miguel and pulls them over after they found out where they were. The cop tells Hanson to get in the police vehicle while he “goes and talks to the boy”. The cop takes Hanson's driver's license and keys and searches his pickup truck, but never actually talks to Miguel. Realizing the officer is corrupt, Hanson escapes from the police car, subdues the officer and retrieves his keys. A short while later, Mauricio and the rest of the cartel catch up with the corrupt officer and kill him while Hanson and Miguel watch from a distance.

Hanson and Miguel continue to make their way north.While staying at a motel, Hanson bribes the receptionist to not register him and Miguel as guests before the cartel shows up and during the escape, they kill Hanson's dog, Jax.

The patch on the truck's radiator fails while attempting to get away from the cartel and they are forced to stop. Eventually Mauricio and his men catch up to Hanson and a firefight breaks out on a nearby farm. Hanson manages to kill three of the cartel members, but Mauricio captures Miguel.

After a skirmish, Hanson is stabbed but seriously wounds Mauricio with a gunshot. Hanson offers him a coup de grâce leaving a single bullet in his gun or a choice to shoot Hanson. As Hanson and Miguel leave the farm, they hear a gunshot, indicating that Mauricio chose to commit suicide.

The pair eventually reach Miguel's family in Chicago, and ends with Hanson getting on a city bus. Realizing he's been fatally wounded, he finally closes his eyes and falls unconscious, presumably dying.